Drug Interaction Report

Ceritinib may increase the blood levels and effects of galantamine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience increased side effects (e.G., nausea, vomiting, abdominal pain, diarrhea, changes in heart rate, seizures, trouble breathing, salivation, tearing, sweating, dizziness, trouble urinating) or if your condition changes. You should also drink plenty of fluids throughout the day to reduce the severity of certain side effects related to galantamine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Do not consume grapefruit or grapefruit juice during treatment with ceritinib unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of ceritinib to dangerous levels, increasing the risk of an irregular heart rhythm that may be serious. Other, more common side effects such as diarrhea, nausea, vomiting, abdominal pain, and hyperglycemia (high blood sugar) may also increase. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with ceritinib. Food may also increase the blood levels of ceritinib. Therefore, you should take ceritinib on an empty stomach, meaning no food should be eaten for at least two hours before or after taking ceritinib. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Galantamine should be taken with food, and you should drink plenty of fluids throughout the day to reduce the severity of certain side effects such as nausea, vomiting, diarrhea, loss of appetite, and/or weight loss. Extended-release formulations should be swallowed whole (i.E., do not crush, chew, or divide the pill) and are often recommended to be taken in the morning. You should speak with your healthcare provider before using grapefruit products (fruit, juice, supplements) with galantamine as they may increase the blood levels and side effects of galantamine. You should also contact your healthcare provider if you experience changes in your heart rate, seizures, difficulty breathing, trouble urinating, dizziness, fainting, nausea, vomiting, diarrhea, and/or unexpected weight loss. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.