Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Fluxid (famotidine)
- probenecid
Interactions between your drugs
probenecid famotidine
Applies to: probenecid, Fluxid (famotidine)
Probenecid may inhibit the tubular secretion of famotidine and thereby increase its pharmacologic effects. The clinical significance of this interaction is uncertain.
References (1)
- Inotsume N, Nishimura M, Nakano M, Fujiyama S, Sato T (1990) "The inhibitory effect of probenecid on renal excretion of famotidine in young, healthy volunteers." J Clin Pharmacol, 30, p. 50-6
Drug and food interactions
famotidine food
Applies to: Fluxid (famotidine)
H2 antagonists may reduce the clearance of nicotine. Cimetidine, 600 mg given twice a day for two days, reduced clearance of an intravenous nicotine dose by 30%. Ranitidine, 300 mg given twice a day for two days, reduced clearance by 10%. The clinical significance of this interaction is not known. Patients should be monitored for increased nicotine effects when using the patches or gum for smoking cessation and dosage adjustments should be made as appropriate.
References (1)
- Bendayan R, Sullivan JT, Shaw C, Frecker RC, Sellers EM (1990) "Effect of cimetidine and ranitidine on the hepatic and renal elimination of nicotine in humans." Eur J Clin Pharmacol, 38, p. 165-9
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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