Drug Interaction Report
3 potential interactions and/or warnings found for the following 2 drugs:
- Estratab (esterified estrogens)
- fezolinetant
Interactions between your drugs
esterified estrogens fezolinetant
Applies to: Estratab (esterified estrogens), fezolinetant
Consumer information for this interaction is not currently available.
GENERALLY AVOID: The concurrent use of fezolinetant with systemic estrogen hormone replacement therapy has not been evaluated in prospective clinical trials. Safety and efficacy of this combination are unknown. However, the concomitant use of vaginal estrogen preparations was excluded from this warning in the product labeling for Australia and the United Kingdom.
MANAGEMENT: Due to the lack of clinical data, use of fezolinetant with systemic estrogen-containing hormone replacement therapy is not recommended. Vaginal estrogen preparations may be used according to some authorities.
Drug and food/lifestyle interactions
fezolinetant food/lifestyle
Applies to: fezolinetant
Consuming food or beverages that contain caffeine (e.G., chocolate, coffee, cola drinks, energy drinks, tea) is not recommended while taking fezolinetant. Caffeine may significantly increase the levels of fezolinetant in the blood. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
esterified estrogens food/lifestyle
Applies to: Estratab (esterified estrogens)
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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