Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- acyclovir
- Cerebyx (fosphenytoin)
Interactions between your drugs
acyclovir fosphenytoin
Applies to: acyclovir, Cerebyx (fosphenytoin)
MONITOR: A case report suggests that plasma phenytoin concentrations may be decreased in the presence of acyclovir. Seizure activity may increase. The mechanism is unknown. A similar interaction may theoretically occur with other hydantoins.
MANAGEMENT: The clinician should consider closer clinical and laboratory monitoring if acyclovir therapy is started or stopped in the presence of phenytoin. The dose of phenytoin should be adjusted as clinically indicated. Patients should be advised to report loss of seizure control.
References (1)
- Parmeggiani A, Riva R, Posar A, Rossi PG (1995) "Possible interaction between acyclovir and antiepileptic treatment." Ther Drug Monit, 17, p. 312-5
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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