Polycystic Kidney Disease
Medically reviewed by Drugs.com. Last updated on Feb 13, 2020.
What is Polycystic Kidney Disease?
Polycystic kidney disease causes numerous cysts (non-cancerous growths) to form in both kidneys. It is a genetic disease, meaning you inherit it from your parents.
The kidneys are a pair of bean-shaped organs that sit in the upper part of the abdomen. They filter wastes and extra fluid from the blood, which get passed out of the body in the form of urine. The kidneys also regulate the amount of certain vital substances in the body, such as electrolytes.
As we age, all of us are prone to develop kidney cysts. They are very common. However, with polycystic kidney disease there are many more cysts than normal, and they cause problems in the body.
When polycystic kidney disease causes numerous cysts to form in the kidneys, the kidneys get severely enlarged. The cysts take the place of normal kidney tissue. With less normal kidney tissue, the kidneys cannot function as well.
Eventually the kidneys may fail. This happens in about half of people with the most common type of polycystic kidney disease. When that happens, the patient needs renal replacement therapy. That means dialysis by a machine that acts as a kidney and filters the blood or receiving a kidney transplant. Usually a person can live with polycystic kidney disease for many years before the kidneys fail.
Though its name makes it sound like it only affects the kidneys, polycystic kidney disease can also cause cysts in the liver and pancreas. It can also cause problems in other organs, such as aneurysms in the brain (bulges in the walls of blood vessels, which can leak and cause a stroke).
There are two major types of polycystic kidney disease:
Autosomal dominant polycystic kidney disease. This is the most common form, making up about 90% of all cases of polycystic kidney disease. If one of your parents has this disease, you have a 50% chance of inheriting it.
Autosomal recessive polycystic kidney disease. This is a rare form of the disease. It can occur when two people who carry the gene for the disease have children. The parents don't have the disease themselves, and probably don't know they are carrying the problematic gene. It only occurs in one-fourth of the children of couples who both carry the gene.
Autosomal dominant polycystic kidney disease
The two most common symptoms are headaches and pain in the back and the sides, between the ribs and hips. The pain may be mild or severe; it may come and go or be persistent.
Autosomal dominant polycystic kidney disease can also cause
urinary tract infections
blood in the urine (hematuria)
high blood pressure
Many people live with autosomal dominant polycystic kidney disease for several decades before symptoms develop. For this reason, you may hear the disease referred to as "adult polycystic kidney disease."
Autosomal recessive polycystic kidney disease
Autosomal recessive polycystic kidney disease often causes symptoms in babies even before they are born. For this reason, it is often called "infantile PKD." Children with this disease often experience
high blood pressure
urinary tract infections
low blood cell counts
growth problems or smaller than average size
kidney failure during childhood
The severity of autosomal recessive polycystic kidney disease varies. It can cause death in babies with the most severe forms, while other people live with it into adulthood without experiencing any symptoms.
Doctors use imaging studies to diagnose both types of polycystic kidney disease, usually ultrasound. Ultrasound uses sound waves to produce images of structures inside the body. On an ultrasound, a doctor can spot cysts on the kidneys that are one-half inch or bigger. Doctors can also use other imaging tests, such as computerized tomography (CT) scans and magnetic resonance imaging (MRI). MRI can measure the volume of cysts, and may help doctors track the progression of the disease.
Through blood tests, doctors can look for genetic mutations that are known to cause polycystic kidney disease. This test can diagnose the autosomal dominant version of the disease before large cysts develop, allowing someone with a mutation to do their best to preserve kidney function by eating well and keeping blood pressure under control. However, the test cannot predict when symptoms will start or how severe the disease will be. The test can be used by people with a family history of polycystic kidney disease to see if they will pass the gene on to their children.
Polycystic kidney disease is a life-long condition, but the severity of the disease varies a lot from person to person.
Since polycystic kidney disease is a genetic disease, there is nothing you can do to prevent it. Whether you get it is purely a matter of what genes you inherit from your parents.
Unfortunately, there is no cure for polycystic kidney disease. However, treatment can relieve symptoms and help you live a longer, healthier life. Here is information on treating the common symptoms of polycystic kidney disease:
Over-the-counter pain medications can help ease pain in the abdomen. Note, though, that it is important to talk to your doctor about which pain medications you should use â some over-the-counter and prescription pain medications can damage the kidneys. Surgery to shrink the cysts can also relieve pain.
If you have severe or recurring headaches, see your doctor before you try to treat them with over-the-counter medication. Headaches can be caused by high blood pressure, which would need to be treated in order to help control the headaches and prevent other health problems. A very severe headache might be caused by a ruptured aneurysm in the brain. This is a medical emergency that requires immediate treatment.
Urinary tract infections
Antibiotics can treat urinary tract infections (UTIs), which occur frequently in people with polycystic kidney disease. If you have symptoms of a UTI, such as pain when you urinate or a frequent urge to urinate, see your doctor immediately. The infection needs to be treated quickly to prevent it from spreading from the urinary tract to the cysts in the kidneys, where infections are harder to treat.
High blood pressure
Keeping blood pressure under control is especially important for people with autosomal dominant polycystic kidney disease because it can slow the disease's effects on the kidneys. Eating a low-salt diet rich in fruits, vegetables and whole grains can help lower blood pressure. Also you should avoid tobacco products and exercise regularly.
Medication is often needed for blood pressure control. The most effective treatment for people with this disorder is an angiotensin converting enzyme inhibitor (ACE inhibitor) or angiotensin receptor blocker (ARB). If blood pressure is still high, a diuretic and/or beta blocker can be added.
Polycystic kidney disease can eventually cause the kidneys to fail. When the kidneys stop working, either dialysis or kidney transplant is needed so that toxins continue to get filtered out of the blood. A person cannot live without this filtering activity.
Dialysis can be done in one of two ways, and it needs to be done regularly and continuously until a kidney transplant takes place.
In hemodialysis, the patient is hooked up to a dialysis machine, and the blood circulates through an external filter. The clean blood reenters the body.
In peritoneal dialysis, a cleansing solution is infused daily into the abdomen. The solution stays in the abdomen for several hours, and then it drains out, along with waste products. Most people do this at night while asleep.
Surgery that transplants a healthy kidney into a person with polycystic kidney disease is the preferred treatment for kidney failure. After a transplant, cysts will not develop on the new, healthy kidney. However, receiving an organ transplant means that you need to take drugs to suppress the immune system for the rest of your life in order to prevent your body from rejecting the transplanted organ. These drugs make you more likely to get infections.
In children with autosomal recessive polycystic kidney disease, eating increased amounts of nutritious food can improve growth. Growth hormone may also be used.
When To Call a Professional
If you have pain in the abdomen, especially if it's accompanied by painful urinations or blood in the urine, see your doctor. If your baby has high blood pressure and pain or blood when urinating, tell your pediatrician. If you have polycystic kidney disease and experience a severe headache, call 911 or go to an emergency room.
People with polycystic kidney disease can live for decades without it causing serious kidney problems. Keeping blood pressure under control by having a healthy lifestyle or taking medications can help ward off serious problems. However, especially with autosomal recessive polycystic kidney disease, the disease's severity varies from person to person.
Learn more about Polycystic Kidney Disease
IBM Watson Micromedex
Mayo Clinic Reference
American Association of Kidney Patients
3505 East Frontage Road, Suite 315
Tampa, FL 33607
Phone: 1â800â749â2257 or 813â636â8100
National Kidney Foundation
30 East 33rd Street
New York, NY 10016
Phone: 1â800â622â9010 or 212â889â2210
National Kidney and Urologic Diseases Information Clearinghouse
3 Information Way
Bethesda, MD 20892â3580
Polycystic Kidney Disease Foundation
9221 Ward Parkway, Suite 400
Kansas City, MO 64114â3367
Phone: 1â800âPKDâCURE (753â2873) or 816â931â2600
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