Astagraf XL and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Astagraf XL (tacrolimus).
Tacrolimus Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Consumption of food has led to a 27% decrease in the bioavailability of orally administered tacrolimus.
MANAGEMENT: Tacrolimus should be administered at least one hour before or two hours after meals.
GENERALLY AVOID: Grapefruit juice has been reported to increase tacrolimus trough concentrations. Data are limited, but inhibition of the CYP450 enzyme system appears to be involved.
MANAGEMENT: The clinician may want to recommend that the patient avoid ingesting large amounts of grapefruit juice while taking tacrolimus.
References (2)
- (2001) "Product Information. Prograf (tacrolimus)." Fujisawa
- Hooks MA (1994) "Tacrolimus, a new immunosuppressant--a review of the literature." Ann Pharmacother, 28, p. 501-11
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Tacrolimus High Blood Pressure (Hypertension)
Moderate Potential Hazard, Moderate plausibility
tacrolimus - hypertension
The use of tacrolimus has been associated with hypertension. Therapy with tacrolimus should be administered cautiously in patients with elevated blood pressure. Close monitoring of blood pressure is recommended.
References (1)
- (2001) "Product Information. Prograf (tacrolimus)." Fujisawa
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Astagraf XL drug interactions
There are 872 drug interactions with Astagraf XL (tacrolimus).
Astagraf XL disease interactions
There are 7 disease interactions with Astagraf XL (tacrolimus) which include:
- diabetes mellitus
- hepatic dysfunction
- infections
- QT interval prolongation
- renal dysfunction
- hyperkalemia
- hypertension
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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