Kalexate (sodium polystyrene sulfonate) and Alcohol/Food Interactions
There are 3 alcohol/food/lifestyle interactions with Kalexate (sodium polystyrene sulfonate) which include:
sodium polystyrene sulfonate multivitamins with minerals
Moderate Drug Interaction
Sodium polystyrene sulfonate can bind to calcium, iron, magnesium, and other minerals in the gastrointestinal tract. This may inactivate both sodium polystyrene sulfonate and the mineral it binds to and reduce the effectiveness of both medications. To avoid or minimize the interaction, the dosing times of sodium polystyrene sulfonate and multivitamin with minerals should be separated by several hours. Talk to your doctor if you have any questions or concerns, or if you have trouble separating the dosing times. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
sodium polystyrene sulfonate food
Moderate Food Interaction
Foods high in potassium such as orange juice and other fruit juices may reduce the effectiveness of sodium polystyrene sulfonate in treating your condition. Do not mix sodium polystyrene sulfonate in fruit juice or drink fruit juice with it. Also, sodium polystyrene sulfonate may interfere with the absorption of other medications that you take by mouth, including both prescription medications such as antibiotics, blood pressure/heart medications and blood thinners, and over-the-counter products such as antacids and laxatives. This can lead to lower blood levels and reduced effects if you take them too closely together with sodium polystyrene sulfonate. It is recommended that you separate the dosing of sodium polystyrene sulfonate from other oral medications by at least 3 hours whenever possible. This interval should be increased to 6 hours if you have gastroparesis or other conditions that cause delayed emptying of food from the stomach into the intestine. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
High Blood Pressure (Hypertension)
Major Potential Hazard, Moderate plausibility
sodium polystyrene sulfonate - sodium load
The use of sodium polystyrene sulfonate is associated with an elevation in sodium. Therapy with sodium polystyrene sulfonate should be administered cautiously in patients with conditions that might be exacerbated by additional sodium such as severe congestive heart failure, severe hypertension, or marked edema. Compensatory restriction of sodium intake from other sources may be indicated.
- Meyer I "Sodium polystyrene sulfonate: a cation exchange resin used in treating hyperkalemia." ANNA J 20 (1993): 93-5
- "Product Information. Kayexalate (sodium polystyrene sulfonate)." Sanofi Winthrop Pharmaceuticals, New York, NY.
Kalexate (sodium polystyrene sulfonate) drug interactions
There are 97 drug interactions with Kalexate (sodium polystyrene sulfonate)
Kalexate (sodium polystyrene sulfonate) disease interactions
There are 3 disease interactions with Kalexate (sodium polystyrene sulfonate) which include:
More about Kalexate (sodium polystyrene sulfonate)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
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- En Español
- Drug class: cation exchange resins
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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