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Ripretinib and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with ripretinib which include:


ripretinib food

Moderate Food Interaction

Grapefruit juice may increase the blood levels of certain medications such as ripretinib. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with ripretinib. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

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High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

ripretinib - hypertension

Ripretinib may cause hypertension. It is recommended to control blood pressure prior to initiating therapy and monitor blood pressure as clinically indicated during treatment. Based on severity, withhold treatment with ripretinib and resume at the same or reduced dose or permanently discontinue. Do not initiate ripretinib in patients with uncontrolled hypertension.

Ripretinib drug interactions

There are 196 drug interactions with ripretinib

Ripretinib disease interactions

There are 3 disease interactions with ripretinib which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.