Combivir (lamivudine / zidovudine) and Alcohol / Food Interactions
There are 2 alcohol/food/lifestyle interactions with Combivir (lamivudine / zidovudine) which include:
zidovudine ↔ food
Minor Food Interaction
Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
For clinical details see professional interaction data.
High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Severe Potential Hazard, Moderate plausibility
NRTIs - pancreatitis
The reverse transcriptase inhibitors, didanosine (ddI), zalcitabine (ddC), stavudine (d4T) and lamivudine (3TC), may cause pancreatitis. The incidence is generally low but is approximately 7% with ddI, and up to 15% in pediatric patients given 3TC. Patients with a history of or known risk factors for pancreatitis, such as alcohol abuse or hypertriglyceridemia, should be monitored closely during therapy with these agents. Therapy should be discontinued at the first signs or symptoms suggestive of pancreatitis (e.g., nausea, vomiting, abdominal pain, hyperamylasemia with dysglycemia, rising triglycerides, decreasing serum calcium), and preferably permanently discontinued if clinical pancreatitis develops.
- van Leeuwen R, Katlama C, Kitchen V, Boucher CA, Tubiana R, McBride M, Ingrand D, Weber J, Hill A, McDade H, et al "Evaluation of safety and efficacy of 3TC (lamivudine) in patients with asymptomatic or mildly symptomatic human immunodeficiency virus infection: a phase I/II study." J Infect Dis 171 (1995): 1166-71
- Dolin R, Lambert JS, Morse GD, et al "2',3'-dideoxyinosine in patients with AIDS or AIDS-related complex." Rev Infect Dis 12 (1990): s540-51
- "Product Information. Zerit (stavudine)." Bristol-Myers Squibb, Princeton, NJ.
Combivir (lamivudine / zidovudine) drug Interactions
There are 316 drug interactions with Combivir (lamivudine / zidovudine)
Combivir (lamivudine / zidovudine) disease Interactions
There are 5 disease interactions with Combivir (lamivudine / zidovudine) which include:
Drug Interaction Classification
Do not stop taking any medications without consulting your healthcare provider.