IsonaRif (isoniazid / rifampin) and Alcohol / Food Interactions
There are 2 alcohol/food/lifestyle interactions with IsonaRif (isoniazid / rifampin) which include:
rifAMPin ↔ Alcohol (Ethanol)
Major Drug Interaction
Using isoniazid together with rifAMPin can cause serious side effects that may affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
isoniazid ↔ Alcohol (Ethanol)
Moderate Drug Interaction
Isoniazid may cause liver problems, and taking it with alcohol can increase the risk. You should avoid or limit the use of alcohol while being treated with isoniazid. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
isoniazid ↔ food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
ADJUST DOSING INTERVAL: Administration with food significantly reduces isoniazid absorption, increasing the risk of therapeutic failure or resistance. The mechanism is unknown. In addition, the ingestion of certain histamine-rich fish (e.g., tuna) and cheeses during isoniazid therapy may cause a flushing reaction in some patients. The proposed mechanism is inhibition of monoamine oxidase and histaminase by isoniazid, resulting in histamine intoxication.
MANAGEMENT: Isoniazid should be administered on an empty stomach, one hour before or two hours after meals. Patients who experience symptoms such as flushing, tachycardia, chills, headache, nausea, vomiting, diarrhea, burning sensations, sweating, or shortness of breath after eating certain foods should be advised to avoid them.
- Uragoda CG, Kottegoda SR "Adverse reactions to isoniazid on ingestion of fish with a high histamine content." Tubercle 58 (1977): 83-9
- "Product Information. INH (isoniazid)." Ciba Pharmaceuticals, Summit, NJ.
- Smith CK, Durack DT "Isoniazid and reaction to cheese." Ann Intern Med 88 (1978): 520-1
IsonaRif (isoniazid / rifampin) drug Interactions
There are 883 drug interactions with IsonaRif (isoniazid / rifampin)
IsonaRif (isoniazid / rifampin) disease Interactions
There are 11 disease interactions with IsonaRif (isoniazid / rifampin) which include:
- Liver Disease
- Peripheral Neuropathy
- Hematopoietic Disturbances
- Liver Disease
- Renal Dysfunction
- Enzyme Induction
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
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