Intelence and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Intelence (etravirine).
Etravirine Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Coadministration with food increases the oral bioavailability of etravirine. The mechanism is unknown. Compared to administration following a meal, the systemic exposure (AUC) to etravirine was decreased by about 50% when the drug was administered under fasting conditions. The types of meal studied (ranging from 345 kilocalories containing 17 grams fat to 1160 kilocalories containing 70 grams fat) did not appear to make a difference with respect to impact on etravirine bioavailability.
MANAGEMENT: Etravirine should always be administered following a meal.
References
- (2008) "Product Information. Intelence (etravirine)." Ortho Biotech Inc
Intelence drug interactions
There are 536 drug interactions with Intelence (etravirine).
Intelence disease interactions
There is 1 disease interaction with Intelence (etravirine) which include:
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
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