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Sustiva (efavirenz) and Alcohol / Food Interactions

There are 2 alcohol/food/lifestyle interactions with Sustiva (efavirenz) which include:

Moderate

efavirenz ↔ food

Moderate Food Interaction

Taking efavirenz with food increases the amount of medicine in your body, which may increase the frequency of side effects. You should take efavirenz once a day on an empty stomach, preferably at bedtime. Taking it at bedtime may make some side effects such as dizziness, trouble sleeping, drowsiness, trouble concentrating, and/or unusual dreams less bothersome. However, these symptoms may be more severe if efavirenz is used with alcohol or mood-altering (street) drugs. You should avoid driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Moderate

High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)

Moderate Potential Hazard, Moderate plausibility

efavirenz - cholesterol

Increases in total cholesterol of 10% to 20% have been observed in some uninfected volunteers who were administered efavirenz. Modest elevations of serum triglycerides have also been reported. The effect of efavirenz on total, LDL, and HDL cholesterol has not been well-characterized. Patients with preexisting hyperlipidemia may require closer monitoring during efavirenz therapy, and adjustments made accordingly in their lipid-lowering regimen.

References

  1. "Product Information. Sustiva (efavirenz)." DuPont Pharmaceuticals, Wilmington, DE.

Sustiva (efavirenz) drug Interactions

There are 744 drug interactions with Sustiva (efavirenz)

Sustiva (efavirenz) disease Interactions

There are 3 disease interactions with Sustiva (efavirenz) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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