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Dolutegravir/lamivudine and Alcohol/Food Interactions

There are 3 alcohol/food/lifestyle interactions with dolutegravir / lamivudine.


Multivitamins With Minerals Dolutegravir

Major Drug Interaction

Dolutegravir and multivitamin with minerals should not be taken orally at the same time. Products that contain aluminum, calcium, iron, magnesium and/or other minerals may interfere with the absorption of dolutegravir and reduce its effectiveness in treating HIV infection. You should take dolutegravir at least two hours before or six hours after the multivitamin with minerals dose. Talk to your doctor if you have any questions or concerns, or if you have trouble separating the dosing times. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Dolutegravir Food

Minor Food Interaction

Information for this minor interaction is available on the professional version.


Lamivudine High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)

Major Potential Hazard, Moderate plausibility

NRTIs - pancreatitis

The nucleoside reverse transcriptase inhibitors, didanosine, stavudine, and lamivudine, may cause pancreatitis. The incidence is generally low but is up to 7% with didanosine, and up to 18% in pediatric patients given lamivudine. Patients with a history of or known risk factors for pancreatitis (such as alcohol abuse or hypertriglyceridemia) should be monitored closely during therapy with these agents. Therapy should be discontinued at the first signs/symptoms suggestive of pancreatitis (e.g., nausea, vomiting, abdominal pain, hyperamylasemia with dysglycemia, rising triglycerides, decreasing serum calcium), and preferably permanently discontinued if clinical pancreatitis develops.


  1. (2019) "Product Information. Epivir (lamiVUDine)." ViiV Healthcare, SUPPL-39
  2. (2018) "Product Information. Videx (didanosine)." Bristol-Myers Squibb, SUPPL-54
  3. (2018) "Product Information. Zerit (stavudine)." Bristol-Myers Squibb, SUPPL-41

Dolutegravir/lamivudine drug interactions

There are 202 drug interactions with dolutegravir / lamivudine.

Dolutegravir/lamivudine disease interactions

There are 7 disease interactions with dolutegravir / lamivudine which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.