Dabrafenib and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with dabrafenib.
Dabrafenib Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food may reduce as well as delay the absorption of dabrafenib. In study subjects, administration of dabrafenib with a high-fat meal decreased peak plasma concentration (Cmax) and systemic exposure (AUC) by 51% and 31%, respectively, and delayed median Tmax by approximately 3.6 hours compared to administration in the fasted state.
MANAGEMENT: Dabrafenib should be taken at least 1 hour before or 2 hours after a meal.
References (1)
- (2013) "Product Information. Tafinlar (dabrafenib)." GlaxoSmithKline
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Dabrafenib drug interactions
There are 506 drug interactions with dabrafenib.
Dabrafenib disease interactions
There are 7 disease interactions with dabrafenib which include:
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- Drug class: multikinase inhibitors
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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