Tafinlar and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Tafinlar (dabrafenib).
Dabrafenib Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food may reduce as well as delay the absorption of dabrafenib. In study subjects, administration of dabrafenib with a high-fat meal decreased peak plasma concentration (Cmax) and systemic exposure (AUC) by 51% and 31%, respectively, and delayed median Tmax by approximately 3.6 hours compared to administration in the fasted state.
MANAGEMENT: Dabrafenib should be taken at least 1 hour before or 2 hours after a meal.
References
- (2013) "Product Information. Tafinlar (dabrafenib)." GlaxoSmithKline
Tafinlar drug interactions
There are 475 drug interactions with Tafinlar (dabrafenib).
Tafinlar disease interactions
There are 7 disease interactions with Tafinlar (dabrafenib) which include:
More about Tafinlar (dabrafenib)
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Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.