Symtuza and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Symtuza (cobicistat / darunavir / emtricitabine / tenofovir alafenamide).
Moderate Food Interaction
Consumer information for this interaction is not currently available.
ADJUST DOSING INTERVAL: Food enhances the absorption and oral bioavailability of darunavir administered in combination with low-dose ritonavir. The mechanism is unknown. When administered with food, the peak plasma concentration (Cmax) and area under the plasma concentration-time curve (AUC) of darunavir were approximately 30% higher than when administered in the fasting state. Darunavir exposure was similar for the range of meals studied. The total caloric content of the various meals evaluated ranged from 240 Kcal (12 grams fat) to 928 Kcal (56 grams fat).
MANAGEMENT: To ensure maximal oral absorption, darunavir coadministered with ritonavir should be taken with food. The type of food is not important.
- "Product Information. Prezista (darunavir)." Ortho Biotech Inc (2006):
Minor Food Interaction
Information for this minor interaction is available on the professional version.
Symtuza drug interactions
There are 685 drug interactions with Symtuza (cobicistat / darunavir / emtricitabine / tenofovir alafenamide).
Symtuza disease interactions
There are 11 disease interactions with Symtuza (cobicistat / darunavir / emtricitabine / tenofovir alafenamide) which include:
- hepatitis B
- renal dysfunction
- creatinine clearance
- renal dysfunction
- bone toxicity
- liver disease
More about Symtuza (cobicistat / darunavir / emtricitabine / tenofovir alafenamide)
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- FDA approval history
- Drug class: antiviral combinations
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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