Entereg and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Entereg (alvimopan).
Alvimopan Food
Minor Food Interaction
Coadministration with a high-fat meal may decrease the rate and extent of alvimopan absorption. According to the product labeling, alvimopan peak plasma concentration (Cmax) and systemic exposure (AUC) were decreased by approximately 38% and 21%, respectively, and the time to reach peak plasma concentration (Tmax) was prolonged by approximately 1 hour when taken with a high-fat meal. The clinical significance is unknown. In postoperative ileus clinical trials, the preoperative dose of alvimopan was administered in a fasting state, and subsequent doses were given without regard to meals.
References (1)
- (2008) "Product Information. Entereg (alvimopan)." GlaxoSmithKline
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Entereg drug interactions
There are 41 drug interactions with Entereg (alvimopan).
Entereg disease interactions
There is 1 disease interaction with Entereg (alvimopan) which include:
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- Drug class: peripheral opioid receptor antagonists
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
