Xyrem Drug Interactions
Currently displaying a list of 346 drugs known to interact with Xyrem (sodium oxybate).
- 244 major drug interactions
- 102 moderate drug interactions
Medications known to interact with Xyrem
Note: Showing generic names only.
A
- acebutolol
- acetylcarbromal
- acrivastine
- aldesleukin
- alfentanil
- alfuzosin
- alprazolam
- amiloride
- amitriptyline
- amlodipine
- amoxapine
- amyl nitrite
- apomorphine
- apraclonidine ophthalmic
- aprocitentan
- aripiprazole
- asenapine
- atenolol
- azatadine
- azilsartan medoxomil
B
- baclofen
- benazepril
- bendroflumethiazide
- benzthiazide
- bepridil
- betaxolol
- bisoprolol
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- bumetanide
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- cabergoline
- candesartan
- cannabidiol
- cannabis
- captopril
- carbamazepine
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carvedilol
- cenobamate
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- chlorzoxazone
- citalopram
- clemastine
- clevidipine
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- codeine
- cyclizine
- cyclobenzaprine
- cyproheptadine
D
- dantrolene
- daridorexant
- deserpidine
- desflurane
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dezocine
- diazepam
- diazoxide
- difelikefalin
- diltiazem
- dimenhydrinate
- diphenhydramine
- diphenhydramine topical
- divalproex sodium
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- droperidol
E
- efavirenz
- enalapril
- enalaprilat
- enflurane
- entacapone
- eplerenone
- eprosartan
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- ethosuximide
- ethotoin
- etomidate
- ezogabine
F
- felbamate
- felodipine
- fenfluramine
- fenoldopam
- fentanyl
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosinopril
- fosphenytoin
- fospropofol
- furosemide
G
H
- halazepam
- haloperidol
- halothane
- heroin
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxyzine
I
- ifosfamide
- iloperidone
- imipramine
- indapamide
- irbesartan
- isocarboxazid
- isoflurane
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
K
L
- labetalol
- lacosamide
- lamotrigine
- landiolol
- lemborexant
- levamlodipine
- levetiracetam
- levodopa
- levomethadyl acetate
- levorphanol
- lisinopril
- lithium
- lofexidine
- lorazepam
- losartan
- loxapine
- lumateperone
- lurasidone
M
- maprotiline
- meclizine
- melatonin
- meperidine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methdilazine
- methocarbamol
- methohexital
- methotrimeprazine
- methoxyflurane
- methsuximide
- methyclothiazide
- methyldopa
- metoclopramide
- metolazone
- metoprolol
- mibefradil
- midazolam
- minoxidil
- mirtazapine
- moexipril
- molindone
- morphine
- morphine liposomal
N
- nabilone
- nadolol
- nalbuphine
- nebivolol
- nefazodone
- nicardipine
- nifedipine
- nimodipine
- nisoldipine
- nitroglycerin
- nitroprusside
- nitrous oxide
- nortriptyline
O
- olanzapine
- oliceridine
- olmesartan
- olopatadine nasal
- opicapone
- opium
- orphenadrine
- oxazepam
- oxcarbazepine
- oxycodone
- oxymorphone
P
- paliperidone
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentolamine
- phenytoin
- pimozide
- pindolol
- polythiazide
- pramipexole
- prazosin
- pregabalin
- primidone
- prochlorperazine
- promazine
- promethazine
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- pyrilamine
Q
R
- ramelteon
- ramipril
- rauwolfia serpentina
- remifentanil
- remimazolam
- reserpine
- risperidone
- ropeginterferon alfa-2b
- ropinirole
- rotigotine
- rufinamide
S
- scopolamine
- secobarbital
- sertraline
- sevoflurane
- sibutramine
- silodosin
- sotalol
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sufentanil
- suvorexant
T
- tamsulosin
- tapentadol
- tasimelteon
- telmisartan
- temazepam
- terazosin
- tetrabenazine
- thalidomide
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- timolol
- tirzepatide
- tizanidine
- tolcapone
- topiramate
- torsemide
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- triamterene
- triazolam
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
V
Z
Xyrem alcohol/food interactions
There are 3 alcohol/food interactions with Xyrem (sodium oxybate).
Xyrem disease interactions
There are 6 disease interactions with Xyrem (sodium oxybate) which include:
- depression
- hx drug/alcohol abuse
- glaucoma
- liver disease
- sensitivity to salt intake
- sleep apnea/respiratory depression
Report options
QR code containing a link to this page
More about Xyrem (sodium oxybate)
- Xyrem consumer information
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (108)
- Drug images
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: miscellaneous anxiolytics, sedatives and hypnotics
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Lumryz
Lumryz (sodium oxybate) is used for the treatment of patients with narcolepsy. Includes Lumryz side ...
Reviews & ratings
Allermax
Allermax is used for allergic reactions, allergic rhinitis, allergies, cold symptoms, cough ...
Reviews & ratings
Featured
Xywav
Xywav is used for the treatment of cataplexy and excessive daytime sleepiness (EDS) in patients ...
Reviews & ratings
Ambien
Ambien (zolpidem) is a prescription sedative used to treat insomnia, helping you fall asleep and ...
Reviews & ratings
Banophen
Banophen is used for allergic reactions, allergic rhinitis, cold symptoms, cough, extrapyramidal ...
Reviews & ratings
Belsomra
Belsomra (suvorexant) is used to treat insomnia. Includes Belsomra side effects, interactions and ...
Reviews & ratings
Benadryl
Benadryl is an antihistamine and is used to treat sneezing, runny nose, itching and other ...
Reviews & ratings
Benadryl Allergy
Benadryl Allergy is used for allergic reactions, allergic rhinitis, allergies, cold symptoms ...
Reviews & ratings
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
