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Drug Interactions between tirzepatide and Xyrem

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

sodium oxybate tirzepatide

Applies to: Xyrem (sodium oxybate) and tirzepatide

Tirzepatide may affect the absorption of oral medications, as it can delay the emptying of stomach content into the intestines. This may impact blood levels and/or the time that it takes for sodium oxybate to become most effective, if sodium oxybate is being administered by mouth or directly into the stomach via a feeding tube. These effects are most apparent at the start of treatment with tirzepatide or after a dose increase and tend to diminish the longer that you are on a stable regimen of tirzepatide. Contact your doctor if you have any questions or notice a change in how any of your oral medications are working. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

sodium oxybate food

Applies to: Xyrem (sodium oxybate)

Food may interfere with the absorption of sodium oxybate. You should wait at least 2 hours after eating before you take the first dose. Avoid alcohol during treatment, as it may add to the central nervous system effects of sodium oxybate and increase the risk of serious side effects such as respiratory depression, low blood pressure, fainting, coma, and even death. Do not drive, operate machinery, or perform other hazardous activities for at least six hours after taking sodium oxybate and until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

tirzepatide food

Applies to: tirzepatide

Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases, this may affect how well and/or how fast those medications work, or it may make no difference. Talk to a healthcare provider if you have any questions or concerns, and contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer