Drug Interactions between Pepcid and regadenoson
This report displays the potential drug interactions for the following 2 drugs:
- Pepcid (famotidine)
- regadenoson
Interactions between your drugs
No interactions were found between Pepcid and regadenoson. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Pepcid
A total of 298 drugs are known to interact with Pepcid.
- Pepcid is in the drug class H2 antagonists.
- Pepcid is used to treat the following conditions:
regadenoson
A total of 6 drugs are known to interact with regadenoson.
- Regadenoson is in the drug class cardiac stressing agents.
- Regadenoson is used to treat the following conditions:
Drug and food interactions
regadenoson food
Applies to: regadenoson
ADJUST DOSING INTERVAL: Caffeine and other xanthine derivatives are nonspecific, competitive antagonists of adenosine receptors. As such, they may interfere with the vasodilating effect of regadenoson, an adenosine receptor agonist. In a placebo-controlled study that assessed the effects of oral caffeine on regadenoson-induced increase in coronary flow reserve (CFR), healthy subjects who took caffeine 200 mg orally two hours prior to regadenoson administration exhibited a median CFR that was 92% that of subjects who took placebo. The study was done using positron emission tomography with radiolabeled water.
MANAGEMENT: Patients should avoid consumption of caffeine-containing products for at least 12 hours prior to administration of regadenoson for myocardial perfusion imaging.
References
- (2008) "Product Information. Lexiscan (regadenoson)." Astellas Pharma US, Inc
famotidine food
Applies to: Pepcid (famotidine)
H2 antagonists may reduce the clearance of nicotine. Cimetidine, 600 mg given twice a day for two days, reduced clearance of an intravenous nicotine dose by 30%. Ranitidine, 300 mg given twice a day for two days, reduced clearance by 10%. The clinical significance of this interaction is not known. Patients should be monitored for increased nicotine effects when using the patches or gum for smoking cessation and dosage adjustments should be made as appropriate.
References
- Bendayan R, Sullivan JT, Shaw C, Frecker RC, Sellers EM (1990) "Effect of cimetidine and ranitidine on the hepatic and renal elimination of nicotine in humans." Eur J Clin Pharmacol, 38, p. 165-9
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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