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Naloxone Drug Interactions

Currently displaying a list of 130 drugs known to interact with naloxone.

See also: The most common drugs checked in combination with this medicine.

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Type in a drug name to check for interactions with naloxone.

Medications known to interact with naloxone

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    • guaifenesin / hydrocodone (Hydrocod-GF, Vitussin Expectorant, Narcof, Condasin, Obredon, Vicodin Tuss, Monte-G HC, Flowtuss, CodiCLEAR DH, Maxi-Tuss HCG, EndaCof-Tab, Ztuss ZT, Tusso-HC, Execlear, Hycotuss Expectorant, Pneumotussin HC, Propatuss Expectorant, Kwelcof, Vi-Q-Tuss, Co-Tussin, Codotuss, Fentuss Expectorant, Co-Tuss V Expectorant, Vicoclear, Endacof XP, Hycosin Expectorant, Vicotuss, G-Tuss, Hycoclar Tuss, Cotuss V, Hydrotuss, Gua HC, Hycoclear, Medcodin, Vortex, Pneumotussin 2.5, Entuss, Pneumotussin, Tusso-DF, Execof, Pancof XP, Touro HC, Xpect-HC, Atuss HX, Extendryl HC, Hydro-Tussin HG, Canges-XP, Z-Cof HCX, Tussicle, A-Cof DH, Relasin-HCX)
    • guaifenesin / hydrocodone / pheniramine / phenylephrine / phenylpropanolamine (S-T Forte)
    • guaifenesin / hydrocodone / pheniramine / phenylpropanolamine / pyrilamine
    • guaifenesin / hydrocodone / phenylephrine (Mintuss G, Atuss G, Ambi 5/15/100, Tussafed-HC, Levall 5.0, Hydro GP, De-Chlor G, Dynatuss HC, Tussafed-HCG, Uni-Lev 5.0, Crantex HC, Duratuss HD, Simuc-HD, Gentex HC, Donatussin DC, Guiaplex HC, Exetuss-HC, Qual-Tussin DC, Nariz HC, MonteFlu HC, Nazarin HC, HydroFed)
    • guaifenesin / hydrocodone / pseudoephedrine (Hycofenix, Entuss-D JR, Decotuss-HD, Vanex Expectorant, Tussadur-HD, Tussend Expectorant, Detussin Expectorant, Tussgen Expectorant, SRC Expectorant, Nalex Expectorant, Deconamine CX, Poly-Tussin XP, Entuss-D, Hydrotussin HD, KG-Tuss HD, Medtuss HD, Spantuss HD, Vanacon, Su-Tuss HD Elixir, Tussafin Liquid, Hytussin Expectorant, Drituss HD, Hydro-Tuss XP, Dynex HD, Entex HC, Pseudatex HC)
    • guaifenesin / hydromorphone (Dilaudid Cough Syrup)
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    • meperidine (Demerol, Meperitab)
    • meperidine / promethazine (Meprozine, Mepergan, Mepergan Fortis)
    • methadone (Methadose, Dolophine, Methadone Diskets, Methadose Sugar-Free)
    • morphine (MS Contin, Morphine Sulfate ER, Morphine Sulfate IR, Roxanol, Kadian, MorphaBond ER, Duramorph, MSIR, Statex, Morphine Sulfate SR, Avinza, Arymo ER, M-Eslon, Astramorph PF, Oramorph SR, Morphine Rapi-Ject, Infumorph, Morphine LP Epidural, RMS, Mitigo, Duramorph PF, OMS, Roxanol 100, Rescudose, MS/S, Roxanol-T, Doloral, Doloral Sirop, Morphitec, M O S)
    • morphine / naltrexone (Embeda)
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    • opium (Paregoric, Opium Tincture, Deodorized, Opium Deodorized)
    • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, Oxyfast, Oxecta, RoxyBond, Percolone, Dazidox, Oxydose, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol)
    • oxymorphone (Opana, Opana ER, Numorphan HCl, Numorphan)
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    • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, ConZip, Ultram ER, Zydol, Tramahexal, Zamadol, Ryzolt, Tramal SR, Larapam SR, GenRx Tramadol, Tramahexal SR, Tramedo, Zydol XL, Rybix ODT, Ultram ODT)

    Naloxone disease interactions

    There are 4 disease interactions with naloxone which include:

    Drug Interaction Classification

    These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
    Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
    Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
    Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
    Unknown No interaction information available.

    Further information

    Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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