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Drug interactions between Linzess and Trulance

Results for the following 2 drugs:
Linzess (linaclotide)
Trulance (plecanatide)

Interactions between your drugs

There were no interactions found in our database between Linzess and Trulance. However, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.

Linzess

A total of 134 drugs (1100 brand and generic names) are known to interact with Linzess.

Trulance

A total of 1 drugs (2 brand and generic names) are known to interact with Trulance.

Drug and food interactions

Moderate

linaclotide food

Applies to: Linzess (linaclotide)

Taking linaclotide with food may increase gastrointestinal side effects such as diarrhea, abdominal pain, and gas. The absorption of any other oral medication you may take can be affected if you develop frequent or severe diarrhea. To reduce the risk of gastrointestinal intolerance, linaclotide should be taken on an empty stomach at least 30 minutes prior to the first meal of the day. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Gastrointestinal stimulants

Therapeutic duplication

The recommended maximum number of medicines in the 'gastrointestinal stimulants' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'gastrointestinal stimulants' category:

  • linaclotide (active ingredient in Linzess (linaclotide))
  • plecanatide (active ingredient in Trulance (plecanatide))

Note: The benefits of taking this combination of medicines may outweigh any risks associated with therapeutic duplication. This information does not take the place of talking to your doctor. Always check with your healthcare provider to determine if any adjustments to your medications are needed.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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