Drug Interactions between levofloxacin and Xanax
This report displays the potential drug interactions for the following 2 drugs:
- levofloxacin
- Xanax (alprazolam)
Interactions between your drugs
No interactions were found between levofloxacin and Xanax. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
levofloxacin
A total of 500 drugs are known to interact with levofloxacin.
- Levofloxacin is in the drug class quinolones and fluoroquinolones.
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Levofloxacin is used to treat the following conditions:
- Anthrax
- Anthrax Prophylaxis
- Bacterial Infection
- Bladder Infection
- Bronchitis
- Chlamydia Infection
- Epididymitis, Sexually Transmitted
- Gonococcal Infection, Disseminated
- Gonococcal Infection, Uncomplicated
- Kidney Infections
- Nongonococcal Urethritis
- Nosocomial Pneumonia
- Otitis Media (off-label)
- Pelvic Inflammatory Disease
- Plague
- Plague Prophylaxis
- Pneumonia
- Prostatitis
- Sinusitis
- Skin and Structure Infection
- Skin or Soft Tissue Infection
- Streptococcal Infection
- Tuberculosis, Active
- Urinary Tract Infection
Xanax
A total of 549 drugs are known to interact with Xanax.
- Xanax is in the drug class benzodiazepines.
- Xanax is used to treat the following conditions:
Drug and food interactions
ALPRAZolam food
Applies to: Xanax (alprazolam)
GENERALLY AVOID: The pharmacologic activity of oral midazolam, triazolam, and alprazolam may be increased if taken after drinking grapefruit juice. The proposed mechanism is CYP450 3A4 enzyme inhibition. In addition, acute alcohol ingestion may potentiate CNS depression and other CNS effects of many benzodiazepines. Tolerance may develop with chronic ethanol use. The mechanism may be decreased clearance of the benzodiazepines because of CYP450 hepatic enzyme inhibition. Also, it has been suggested that the cognitive deficits induced by benzodiazepines may be increased in patients who chronically consume large amounts of alcohol.
MANAGEMENT: The manufacturer recommends that grapefruit juice should not be taken with oral midazolam. Patients taking triazolam or alprazolam should be monitored for excessive sedation. Alternatively, the patient could consume orange juice which does not interact with these drugs. Patients should be advised to avoid alcohol during benzodiazepine therapy.
References
- "Product Information. Xanax (alprazolam)." Pharmacia and Upjohn PROD (2002):
- "Product Information. Valium (diazepam)." Roche Laboratories PROD (2002):
- "Product Information. Halcion (triazolam)." Pharmacia and Upjohn PROD (2001):
- "Grapefruit juice interactions with drugs." Med Lett Drugs Ther 37 (1995): 73-4
- Kupferschmidt HHT, Ha HR, Ziegler WH, Meier PJ, Krahenbuhl S "Interaction between grapefruit juice and midazolam in humans." Clin Pharmacol Ther 58 (1995): 20-8
- Hukkinen SK, Varhe A, Olkkola KT, Neuvonen PJ "Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice." Clin Pharmacol Ther 58 (1995): 127-31
- Bailey DG, Dresser GR, Kreeft JH, Munoz C, Freeman DJ, Bend JR "Grapefruit-felodipine interaction: Effect of unprocessed fruit and probable active ingredients." Clin Pharmacol Ther 68 (2000): 468-77
levoFLOXacin food
Applies to: levofloxacin
ADJUST DOSING INTERVAL: Food may reduce the oral absorption and bioavailability of levofloxacin. According to the drug product labeling, administration of levofloxacin 500 mg with food prolonged the time to peak concentration by 1 hour and decreased the Cmax decreased by 25% following administration of the oral solution and by 14% following administration of the oral tablet.
MANAGEMENT: To ensure maximal and consistent oral absorption, levofloxacin oral solution should be taken at least one hour before or two hours after meals. For administration of the oral solution with continuous enteral nutrition, some experts recommend that the tube feeding should be interrupted for one hour before and two hours after the dose of levofloxacin. The oral tablets may be taken without regard to food.
References
- Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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