Xanax (alprazolam) Drug Interactions
A total of 955 drugs are known to interact with Xanax (alprazolam).
- 138 major drug interactions
- 709 moderate drug interactions
- 108 minor drug interactions
Check for interactions
Most frequently checked interactions
View interaction reports for Xanax (alprazolam) and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Ambien (zolpidem)
- Benadryl (diphenhydramine)
- BuSpar (buspirone)
- Celexa (citalopram)
- Cymbalta (duloxetine)
- Flexeril (cyclobenzaprine)
- gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
- ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
- levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Euthyrox, Unithroid, Levothyrox, Eutroxsig, Levo-T, Oroxine, L Thyroxine Roche, Levotabs, Novothyrox, Tirosint-Sol, Levotec, Evotrox)
- Lexapro (escitalopram)
- lisinopril (Zestril, Prinivil, Qbrelis)
- Lyrica (pregabalin)
- metformin (Glucophage, Glumetza, Glucophage XR, Fortamet, Riomet)
- Norco (acetaminophen / hydrocodone)
- omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
- oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, RoxyBond, Percolone, Oxecta, Oxydose, Oxyfast, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol, Dazidox)
- prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Meticorten, Orasone, Liquid Pred, Prednicen-M)
- Prozac (fluoxetine)
- Subutex (buprenorphine)
- Synthroid (levothyroxine)
- tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, ConZip, Zydol, Tramal SR, GenRx Tramadol, Zamadol, Ryzolt, Tramedo, Larapam SR, Tramahexal SR, Tramahexal, Zydol XL, Rybix ODT, Ultram ODT)
- trazodone (Desyrel, Oleptro, Desyrel Dividose)
- Tylenol (acetaminophen)
- Vitamin D3 (cholecalciferol)
- Wellbutrin (bupropion)
- wine
- Zoloft (sertraline)
Xanax (alprazolam) alcohol/food interactions
There are 2 alcohol/food interactions with Xanax (alprazolam)
Xanax (alprazolam) disease interactions
There are 9 disease interactions with Xanax (alprazolam) which include:
- acute alcohol intoxication
- closed-angle glaucoma
- drug dependence
- renal/liver disease
- respiratory depression
- seizures
- depression
- obesity
- paradoxical reactions
More about Xanax (alprazolam)
- Xanax Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Patient Tips
- Drug Images
- Compare Alternatives
- Support Group
- Pricing & Coupons
- En Español
- 693 Reviews
- Generic Availability
- Drug class: benzodiazepines
- FDA Alerts (1)
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
