Drug Interactions between Januvia and Rybelsus
This report displays the potential drug interactions for the following 2 drugs:
- Januvia (sitagliptin)
- Rybelsus (semaglutide)
Interactions between your drugs
No interactions were found between Januvia and Rybelsus. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Januvia
A total of 289 drugs are known to interact with Januvia.
- Januvia is in the drug class dipeptidyl peptidase 4 inhibitors.
- Januvia is used to treat Diabetes, Type 2.
Rybelsus
A total of 266 drugs are known to interact with Rybelsus.
- Rybelsus is in the drug class Incretin Mimetics (GLP-1 Agonists).
- Rybelsus is used to treat Diabetes, Type 2.
Drug and food interactions
SITagliptin food
Applies to: Januvia (sitagliptin)
Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. You should avoid using alcohol if your diabetes is not well controlled or if you have high triglycerides, neuropathy (nerve damage), or pancreatitis. Moderate alcohol consumption generally does not affect blood glucose levels if your diabetes is under control. However, it may be best to limit alcohol intake to one drink daily for women and two drinks daily for men (1 drink = 5 oz wine, 12 oz beer, or 1.5 oz distilled spirits) in conjunction with your normal meal plan. Avoid drinking alcohol on an empty stomach or following exercise, as it may increase the risk of hypoglycemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
semaglutide food
Applies to: Rybelsus (semaglutide)
Semaglutide may affect the absorption of other medications that you take by mouth. In some cases, this may affect how well and/or how fast those medications work, or it may make no difference. Talk to a healthcare provider if you have any questions or concerns, and contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Incretin-based therapies
Therapeutic duplication
The recommended maximum number of medicines in the 'incretin-based therapies' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'incretin-based therapies' category:
- Januvia (sitagliptin)
- Rybelsus (semaglutide)
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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