Hydrocodone/phenylephrine Interactions
There are 731 drugs known to interact with hydrocodone/phenylephrine, along with 20 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 231 are major, 497 are moderate, and 3 are minor.
- View all 731 medications that may interact with hydrocodone/phenylephrine
- View hydrocodone/phenylephrine alcohol/food interactions (1)
- View hydrocodone/phenylephrine disease interactions (20)
Most frequently checked interactions
View interaction reports for hydrocodone / phenylephrine and the medicines listed below.
- 5-HTP (5-hydroxytryptophan)
- 5-HTP (5-hydroxytryptophan)
- Adderall XR (amphetamine / dextroamphetamine)
- Adderall XR (amphetamine / dextroamphetamine)
- Advil (ibuprofen)
- Advil (ibuprofen)
- Advil Allergy Sinus (chlorpheniramine / ibuprofen / pseudoephedrine)
- Advil Allergy Sinus (chlorpheniramine / ibuprofen / pseudoephedrine)
- Aspirin Low Strength (aspirin)
- Aspirin Low Strength (aspirin)
- Augmentin (amoxicillin / clavulanate)
- Augmentin (amoxicillin / clavulanate)
- Azithromycin Dose Pack (azithromycin)
- Azithromycin Dose Pack (azithromycin)
- Cymbalta (duloxetine)
- Cymbalta (duloxetine)
- EpiPen (epinephrine)
- EpiPen (epinephrine)
- Lipitor (atorvastatin)
- Lipitor (atorvastatin)
- Lyrica (pregabalin)
- Lyrica (pregabalin)
- Plavix (clopidogrel)
- Plavix (clopidogrel)
- Vitamin D3 (cholecalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Xanax (alprazolam)
- Zoloft (sertraline)
- Zoloft (sertraline)
Hydrocodone/phenylephrine alcohol/food interactions
There is 1 alcohol/food interaction with hydrocodone / phenylephrine.
Hydrocodone/phenylephrine disease interactions
There are 20 disease interactions with hydrocodone / phenylephrine which include:
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- cardiovascular disease
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
- BPH
- diabetes
- glaucoma
Report options
More about hydrocodone / phenylephrine
- Compare alternatives
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.