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Can you take Doxycycline with Magnesium glycinate?

1 drug interaction and 11 additional warnings found for the following 2 drugs:

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Drug interactions

Moderate drug interactions

Moderate:

doxycycline magnesium glycinate

Applies to: doxycycline and magnesium glycinate

Doxycycline and magnesium glycinate should not be taken orally at the same time. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of doxycycline into the bloodstream and reduce its effectiveness.

What to do: If possible, it may be best to avoid taking magnesium glycinate while your are being treated with doxycycline. Otherwise, you should separate dosing by 2 to 4 hours, doxycycline should be taken at least 2 hours before and not less than 6 hours after Suprep Bowel Prep (magnesium/potassium/sodium sulfates), or doxycycline and magnesium glycinate should be taken as directed by your healthcare provider.

Talk to your healthcare provider if you are unsure whether your medications contain something that could potentially interact or if you have questions on how to take this or other medications you are prescribed.

It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food/lifestyle interactions

Moderate food/lifestyle interactions

Moderate:

doxycycline multivitamins with minerals

Applies to: doxycycline

In general, multivitamins with minerals and doxycycline should not be taken orally at the same time.

Products that contain aluminum, calcium, iron, magnesium, zinc and/or other minerals may interfere with the absorption of doxycycline into the bloodstream and reduce its effectiveness in treating your infection.

If possible, it may be best to avoid taking multivitamins with minerals while you are being treated with doxycycline. Otherwise, you should separate their dosing times by as much as possible, usually at least 2 to 4 hours.

Talk to your healthcare provider if you are unsure whether your medications contain something that could potentially interact or if you have questions on how to take this or other medications you are prescribed.

It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Minor food/lifestyle interactions

Minor:

doxycycline Alcohol (Ethanol)

Applies to: doxycycline

Chronic alcohol consumption may enhance the elimination of doxycycline. The mechanism is induction of hepatic microsomal enzymes by alcohol. In one study, the half-life of doxycycline in six alcoholics was 10.5 hours, compared with 14.7 hours in six control patients. In addition, half the alcoholic patients had serum concentrations below what is generally considered the minimum therapeutic concentration (0.5 mcg/mL) at 12 to 24 hours after the dose. The investigators suggest that twice-a-day dosing may be indicated in these patients, especially if additional inducing drugs are used. The elimination of other tetracyclines probably is not affected by alcohol consumption.

The information above is from our professional interaction data. Consumer information is not available for this interaction.

Disease interactions

9 potential interactions Applies to: 8 conditions, including Diabetes Mellitus, Liver Disease, Alcoholism, Noninfectious Colitis, and Renal Dysfunction.

Alcoholism

Moderate:

magnesium glycinate

Magnesium glycinate has a moderate potential interaction with Alcoholism.

Liquids, powders, and some other forms of magnesium glycinate may contain sugar and/or aspartame. Liquid products may also contain alcohol. Caution is advised in patients that have diabetes, alcohol dependence, liver disease, phenylketonuria (PKU), or any other condition that requires to limit or avoid these substances.

Biliary Obstruction

Moderate:

doxycycline

Doxycycline has a moderate potential interaction with Biliary Obstruction.

The use of tetracyclines has rarely been associated with hepatotoxicity. Histologic fatty changes of the liver, elevated liver enzymes, and jaundice have been reported, primarily in patients treated with large doses of intravenous tetracycline hydrochloride (no longer available in the U.S.) but also in patients receiving high oral doses of these drugs. Therapy with tetracyclines should be administered cautiously in patients with preexisting liver disease or biliary obstruction. Reduced dosages may be appropriate, particularly with minocycline and doxycycline, since the former is metabolized by the liver and the latter undergoes enterohepatic recycling. Liver function tests are recommended prior to and during therapy, and the concomitant use of other potentially hepatotoxic drugs should be avoided.

Diabetes Mellitus

Moderate:

magnesium glycinate

Magnesium glycinate has a moderate potential interaction with Diabetes Mellitus.

Liquids, powders, and some other forms of magnesium glycinate may contain sugar and/or aspartame. Liquid products may also contain alcohol. Caution is advised in patients that have diabetes, alcohol dependence, liver disease, phenylketonuria (PKU), or any other condition that requires to limit or avoid these substances.

Esophageal Obstruction

Moderate:

doxycycline

Doxycycline has a moderate potential interaction with Esophageal Obstruction.

The use of oral tetracycline capsules and tablets has been associated with esophageal irritation and ulceration in patients who ingested the drug without sufficient fluid shortly before bedtime. Therapy with solid formulations of tetracyclines should preferably be avoided in patients with esophageal obstruction, compression or dyskinesia. If the drugs are used, patients should be advised not to take the medication just before retiring and to drink fluids liberally.

Liver Disease

Moderate:

doxycycline

Doxycycline has a moderate potential interaction with Liver Disease.

The use of tetracyclines has rarely been associated with hepatotoxicity. Histologic fatty changes of the liver, elevated liver enzymes, and jaundice have been reported, primarily in patients treated with large doses of intravenous tetracycline hydrochloride (no longer available in the U.S.) but also in patients receiving high oral doses of these drugs. Therapy with tetracyclines should be administered cautiously in patients with preexisting liver disease or biliary obstruction. Reduced dosages may be appropriate, particularly with minocycline and doxycycline, since the former is metabolized by the liver and the latter undergoes enterohepatic recycling. Liver function tests are recommended prior to and during therapy, and the concomitant use of other potentially hepatotoxic drugs should be avoided.

Moderate:

magnesium glycinate

Magnesium glycinate has a moderate potential interaction with Liver Disease.

Liquids, powders, and some other forms of magnesium glycinate may contain sugar and/or aspartame. Liquid products may also contain alcohol. Caution is advised in patients that have diabetes, alcohol dependence, liver disease, phenylketonuria (PKU), or any other condition that requires to limit or avoid these substances.

Noninfectious Colitis

Major:

doxycycline

Doxycycline has a major potential interaction with Noninfectious Colitis.

Clostridioides difficile-associated diarrhea (CDAD), formerly pseudomembranous colitis, has been reported with almost all antibacterial drugs and may range from mild diarrhea to fatal colitis. The most common culprits include clindamycin and lincomycin. Antibacterial therapy alters the normal flora of the colon, leading to overgrowth of C difficile, whose toxins A and B contribute to CDAD development. Morbidity and mortality are increased with hypertoxin-producing strains of C difficile; these infections can be resistant to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea after antibacterial use. Since CDAD has been reported to occur more than 2 months after antibacterial use, careful medical history is necessary. Therapy with broad-spectrum antibacterials and other agents with significant antibacterial activity should be administered cautiously in patients with history of gastrointestinal disease, particularly colitis; pseudomembranous colitis (generally characterized by severe, persistent diarrhea and severe abdominal cramps, and sometimes associated with the passage of blood and mucus), if it occurs, may be more severe in these patients and may be associated with flares in underlying disease activity. Antibacterial drugs not directed against C difficile may need to be stopped if CDAD is suspected or confirmed. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation should be started as clinically indicated.

Phenylketonuria

Moderate:

magnesium glycinate

Magnesium glycinate has a moderate potential interaction with Phenylketonuria.

Liquids, powders, and some other forms of magnesium glycinate may contain sugar and/or aspartame. Liquid products may also contain alcohol. Caution is advised in patients that have diabetes, alcohol dependence, liver disease, phenylketonuria (PKU), or any other condition that requires to limit or avoid these substances.

Renal Dysfunction

Major:

magnesium glycinate

Magnesium glycinate has a major potential interaction with Renal Dysfunction.

Magnesium is eliminated by the kidney. The serum concentration of magnesium is increased in patients with renal impairment. Magnesium toxicity includes CNS depression, muscular paralysis, respiratory depression, hypotension and prolonged cardiac conduction time. Disappearance of the patellar reflex is a useful clinical sign of magnesium intoxication. Therapy with magnesium should be administered cautiously and dosages should be modified in patients with compromised renal function. Clinical monitoring of serum magnesium levels is recommended.

More resources

doxycycline

A total of 246 drugs are known to interact with doxycycline.

magnesium glycinate

A total of 67 drugs are known to interact with magnesium glycinate.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.