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Drug Interactions between buprenorphine / naloxone and Linzess

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

No interactions were found between buprenorphine / naloxone and Linzess. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

buprenorphine / naloxone

A total of 722 drugs are known to interact with buprenorphine / naloxone.

Linzess

A total of 59 drugs are known to interact with Linzess.

Drug and food interactions

Major

buprenorphine food

Applies to: buprenorphine / naloxone

GENERALLY AVOID: Alcohol may potentiate the central nervous system (CNS) depressant effects of opioid analgesics including buprenorphine. Concomitant use may result in additive CNS depression and impairment of judgment, thinking, and psychomotor skills. In more severe cases, hypotension, respiratory depression, profound sedation, coma, or even death may occur.

MANAGEMENT: Patients taking buprenorphine should not consume alcohol or use medications that contain alcohol on days of buprenorphine dosing. In general, potent narcotics such as buprenorphine should not be combined with alcohol.

References (4)
  1. (2023) "Product Information. Sublocade (buprenorphine)." Indivior Inc., SUPPL-28
  2. (2023) "Product Information. Probuphine (buprenorphine)." Titan Pharmaceuticals Inc, SUPPL-14
  3. (2023) "Product Information. Buprenorphine (buprenorphine)." G.L. Pharma UK Ltd
  4. (2023) "Product Information. Temgesic (buprenorphine)." Reckitt Benckiser Pty Ltd
Moderate

linaclotide food

Applies to: Linzess (linaclotide)

ADJUST DOSING INTERVAL: Administration of linaclotide in the fed condition resulted in more gastrointestinal side effects and more frequent and looser stools, than when it was administered under fasting conditions.

MANAGEMENT: It is recommended to take linaclotide 30 minutes before a meal.

References (2)
  1. EMEA. European Medicines Agency (2007) EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid
  2. (2012) "Product Information. Linzess (linaclotide)." Forest Pharmaceuticals

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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