Skip to Content

XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) Drug Interactions

A total of 981 drugs are known to interact with XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine).

  • 250 major drug interactions
  • 694 moderate drug interactions
  • 37 minor drug interactions

Show all medications in the database that may interact with XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine).

Check for interactions

Type in a drug name to check for interactions with XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine).

Most frequently checked interactions

View interaction reports for XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) and the medicines listed below.

  • Adderall (amphetamine / dextroamphetamine)
  • albuterol (Ventolin, Ventolin HFA, ProAir HFA, Proventil, Proventil HFA, ProAir RespiClick, AccuNeb, Respirol, Vospire ER, Volmax, ProAir Digihaler, Airet)
  • Alcohol (contained in alcoholic beverages) (ethanol)
  • Allegra (fexofenadine)
  • atorvastatin (Lipitor)
  • Bayer Aspirin (aspirin)
  • benazepril (Lotensin)
  • cannabis
  • Cheratussin AC (codeine / guaifenesin)
  • Cold & Cough (chlorpheniramine / dextromethorphan)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Sleep, Unisom SleepGels, Sominex, Sleep Tabs, Benadryl Children's Allergy, Dicopanol, Diphen, Nytol, Simply Sleep, Diphenhist, Hydramine, Diphenydramine Quick Melt, Sleepwell 2-nite, Hydramine Cough Syrup, Bydramine, Diphedryl, DPH, Calm-Aid, Diphenadryl, Sleep Tab II, Diphenyl, Altaryl, Quenalin, Diphendryl, Sleep-ettes D, Dytan, Vanamine PD, Unisom SleepMelts, Dormin, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Buckley's Bedtime, Hyrexin, 40 Winks, Diphen AF, Diphen Cough, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Genahist, Alka-Seltzer Plus Allergy, Q-Dryl, Aller-G-Time, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Uni-Tann, Q-Dryl A/F, Diphenmax, Nightime Sleepaid, Ben-Tann, Pharbedryl, Histaprin, Z-Sleep, Tranquil Nighttime Sleep Aid, PediaCare Children's Allergy, Truxadryl, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • Lipitor (atorvastatin)
  • meclizine (Antivert, Bonine, Dramamine II, Meclicot, Dramamine Less Drowsy, Sea-Calm, Travel Sickness, Antrizine, Medivert, D-Vert, Driminate II, Ru-Vert-M, Meni-D, Help I'm Nauseous, Dramamine All Day Less Drowsy, Travel-Ease, Motion-Time, Verticalm)
  • metformin (Glucophage, Glumetza, Glucophage XR, Fortamet, Riomet)
  • Metoprolol Tartrate (metoprolol)
  • OxyContin (oxycodone)
  • paroxetine (Paxil, Paxil CR, Brisdelle, Pexeva)
  • tamsulosin (Flomax)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, ConZip, Zydol, Tramal SR, GenRx Tramadol, Zamadol, Ryzolt, Tramedo, Larapam SR, Tramahexal SR, Tramahexal, Zydol XL, Rybix ODT, Ultram ODT)
  • Wellbutrin (bupropion)

XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) alcohol/food interactions

There is 1 alcohol/food interaction with XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine)

XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) disease interactions

There are 11 disease interactions with XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) which include:

More about XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine)

Related treatment guides

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide