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XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) Drug Interactions

A total of 986 drugs are known to interact with XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine).

  • 250 major drug interactions
  • 698 moderate drug interactions
  • 38 minor drug interactions

Show all medications in the database that may interact with XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine).

Check for interactions

Type in a drug name to check for interactions with XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine).

Most frequently checked interactions

View interaction reports for XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) and the medicines listed below.

  • Adderall (amphetamine / dextroamphetamine)
  • albuterol (Ventolin, Ventolin HFA, ProAir HFA, Proventil, Proventil HFA, ProAir RespiClick, AccuNeb, Respirol, ProAir Digihaler, Volmax, Airet, Vospire ER)
  • Alcohol (contained in alcoholic beverages) (ethanol)
  • Allegra (fexofenadine)
  • atorvastatin (Lipitor)
  • Bayer Aspirin (aspirin)
  • benazepril (Lotensin)
  • cannabis
  • Cheratussin AC (codeine / guaifenesin)
  • Cold & Cough (chlorpheniramine / dextromethorphan)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Sleep, Benadryl Children's Allergy, Diphen, Sominex, Nytol, Diphedryl, Quenalin, Unisom SleepGels, Diphenadryl, Simply Sleep, Dicopanol, Diphenhist, 40 Winks, DPH, Diphenydramine Quick Melt, Hyrexin, Hydramine Cough Syrup, Diphen Cough, Diphenyl, Pharbedryl, Histaprin, Tranquil Nighttime Sleep Aid, Unisom SleepMelts, Dormin, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Buckley's Bedtime, Bydramine, Diphen AF, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Calm-Aid, Genahist, Alka-Seltzer Plus Allergy, Q-Dryl, Aller-G-Time, Sleep Tab II, Sleep Tabs, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Altaryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Hydramine, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Diphendryl, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Q-Dryl A/F, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Z-Sleep, PediaCare Children's Allergy, Truxadryl, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy, Sleepwell 2-nite)
  • ibuprofen (Advil, Motrin, IBU, Motrin IB, Advil Liqui-Gels, Motrin Childrens, Advil Children's, Caldolor, Children's Motrin, Childrens Ibuprofen Berry, Ibuprofen PMR, Nuprin, NeoProfen, Proprinal, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Advil Migraine, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Advil Infant's Concentrated Drops, Motrin Pediatric, Ibu-Tab, Rufen, Genpril, Haltran, IBU-200, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Actiprofen, Motrin Migraine Pain, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Ibu-8, Motrin Junior Strength, Motrin Infant Drops, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Advil Film-Coated)
  • Lipitor (atorvastatin)
  • meclizine (Antivert, Bonine, Dramamine Less Drowsy, Help I'm Nauseous, Dramamine All Day Less Drowsy, Travel Sickness, Medivert, Meclicot, Antrizine, Dramamine II, D-Vert, Driminate II, Ru-Vert-M, Meni-D, Travel-Ease, Motion-Time, Sea-Calm, Verticalm)
  • metformin (Glucophage, Glumetza, Fortamet, Glucophage XR, Riomet)
  • Metoprolol Tartrate (metoprolol)
  • OxyContin (oxycodone)
  • paroxetine (Paxil, Paxil CR, Brisdelle, Pexeva)
  • tamsulosin (Flomax)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Tramahexal, ConZip, Larapam SR, Ryzolt, Tramal SR, GenRx Tramadol, Tramahexal SR, Tramedo, Zydol, Zamadol, Zydol XL, Rybix ODT, Ultram ODT)
  • Wellbutrin (bupropion)

XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) alcohol/food interactions

There is 1 alcohol/food interaction with XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine)

XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) disease interactions

There are 11 disease interactions with XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine) which include:

More about XL-3 Cold Medicine (acetaminophen / chlorpheniramine / phenylephrine)

Related treatment guides

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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