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Peripheral opioid receptor antagonists

What are Peripheral opioid receptor antagonists?

Peripheral opioid receptor antagonists bind to the peripheral opioid receptors, such as those in the gastrointestinal tract and block unwanted effects caused by opioids.

They are not able to penetrate the blood brain barrier so do not antagonize central nervous system opioid receptors, therefore the analgesic effects of opioids is not affected.

Peripheral opioid receptor antagonists are given with opioids to prevent opioid-induced constipation.

List of Peripheral opioid receptor antagonists:

View by  Brand | Generic
Drug Name Reviews Avg. Ratings
alvimopan systemic (Pro)
0 reviews
5.0
methylnaltrexone systemic (Pro)
56 reviews
6.4
naldemedine systemic (Pro)
19 reviews
6.4
naloxegol systemic (Pro)
234 reviews
4.8
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

See Also

Medical conditions associated with peripheral opioid receptor antagonists:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.