What are Loop diuretics
Loop diuretics inhibit the Na+/K+/2Cl- co-transporter in the thick ascending loop of Henle, in the kidneys and stop the transport of sodium chloride out of the tubule into the interstitial tissue, causing a decrease in sodium and chloride re-absorption. They act on the chloride-binding site and have a direct inhibiting effect on the carrier.
Inhibition of this transporter leads to a significant increase in concentration of ions in the tubule and reduced hypertonicity in the surrounding interstitium, causing less water to be reabsorbed into the blood. This causes more urine to be produced and a decrease in blood volume.
List of Loop diuretics:
|Drug Name ( View by: Brand | Generic )||Reviews||Ratings|
|ethacrynic acid systemic (Pro, More...)
|furosemide systemic (Pro, More...)
|bumetanide systemic (Pro, More...)
|torsemide systemic (Pro, More...)
Medical conditions associated with loop diuretics: