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Urokinase Dosage

Applies to the following strength(s): 250000 intl units ; 5000 intl units ; 9000 intl units

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Pulmonary Embolism

Initial dose: 4400 international units/kg IV at a rate of 90 mL/hr over 10 minutes

Maintenance dose: 4400 international units/kg/hr IV at a rate of 15 mL for 12 hours

Comments:
-Institute treatment soon after onset of pulmonary embolism to avoid potential decrease in efficacy.
-Administration of this drug may be repeated as necessary.
-After infusing this drug, do not begin anticoagulation until activated partial thromboplastin time (aPTT) has decreased to less than twice the normal control value; if heparin is used, do not administer a loading dose of heparin; treatment should be followed by oral anticoagulants.

Uses:
-Lysis of acute massive pulmonary emboli (obstruction of blood flow to a lobe or multiple segments).
-Lysis of pulmonary emboli accompanied by unstable hemodynamics (e.g., failure to maintain blood pressure without supportive measures).

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice: The manufacturer product information should be consulted.

Storage requirements: Refrigerate powder at 2 to 8C (36 to 46F).

Reconstitution/preparation techniques: The manufacturer product information should be consulted.

IV compatibility: This drug should not be mixed with other medicinal products.

Monitoring:
-Hematologic: Hematocrit, platelet count, and activated partial thromboplastin time (aPTT) should be obtained prior to starting treatment
-General: Vital signs should be observed frequently during and following infusion (blood pressure should not be taken in lower extremities to avoid dislodgement of possible deep vein thrombus)

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