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Uridine Dosage

Medically reviewed on June 25, 2018.

Applies to the following strengths: triacetate 10 g; 2 g

Usual Adult Dose for Fluorouracil/Capecitabine Overdose

10 grams (1 packet) orally every 6 hours for 20 doses

Comments: Each dose should be mixed with 3 to 4 ounces of soft foods such as applesauce, pudding, or yogurt, and ingested within 30 minutes along with 4 ounces of water.

Use: Emergency treatment of a fluorouracil or capecitabine overdose regardless of the presence of symptoms, or for patients who exhibit early-onset, severe, or life-threatening toxicity affecting the cardiac or central nervous system, and/or early-onset, unusually severe adverse reactions (e.g., gastrointestinal toxicity and/or neutropenia) within 96 hours following the end of fluorouracil or capecitabine administration.

Usual Adult Dose for Orotic Aciduria

Initial Dose: 60 mg/kg orally once a day

Maintenance Dose: Increase dosage to 120 mg/kg orally once a day for insufficient efficacy, such as occurrence of one of the following:
-levels of orotic acid in urine remain above normal or increase above the usual or expected range for the patient;
-laboratory values (e.g., red blood cell or white blood cell indices) affected by hereditary orotic aciduria show evidence of worsening;
-worsening of other signs or symptoms of the disease.

Maximum Dose: 8 grams orally once a day

Comments: For patients requiring doses in multiples of 2 grams (3/4 teaspoon), an entire drug packet(s) may be administered without weighing or measuring.

Use: Treatment of hereditary orotic aciduria

Usual Pediatric Dose for Fluorouracil/Capecitabine Overdose

6.2 grams/m2 BSA orally every 6 hours for 20 doses

Maximum Dose: 10 grams per dose

Comments:
-Measure the dose using either a scale accurate to at least 0.1 gram, or a graduated teaspoon accurate to 1/4 teaspoon.
-Each dose should be mixed with 3 to 4 ounces of soft foods such as applesauce, pudding, or yogurt, and ingested within 30 minutes along with 4 ounces of water.
-Unused granules should be discarded and not used for subsequent dosing.
-Limited clinical data indicates response and safety are similar in pediatric and adult patients.

Use: Emergency treatment of a fluorouracil or capecitabine overdose regardless of the presence of symptoms, or for patients who exhibit early-onset, severe, or life-threatening toxicity affecting the cardiac or central nervous system, and/or early-onset, unusually severe adverse reactions (e.g., gastrointestinal toxicity and/or neutropenia) within 96 hours following the end of fluorouracil or capecitabine administration.

Usual Pediatric Dose for Orotic Aciduria

Initial Dose: 60 mg/kg orally once a day

Maintenance Dose: Increase dosage to 120 mg/kg orally once a day for insufficient efficacy, such as occurrence of one of the following:
-levels of orotic acid in urine remain above normal or increase above the usual or expected range for the patient;
-laboratory values (e.g., red blood cell or white blood cell indices) affected by hereditary orotic aciduria show evidence of worsening;
-worsening of other signs or symptoms of the disease.

Maximum Dose: 8 grams orally once a day

Comments:
-This drug can be mixed with milk or infant formula for patients receiving up to 2 grams (3/4 teaspoon); the manufacturer product information should be consulted for administration instructions.
-For patients requiring doses in multiples of 2 grams (3/4 teaspoon), an entire drug packet(s) may be administered without weighing or measuring.

Use: Treatment of hereditary orotic aciduria

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Other Comments

Administration Advice:
-This drug should be administered as soon as possible after a fluorouracil or capecitabine overdose.
-If a patient vomits within 2 hours of a dose or misses a dose, another complete dose should be initiated as soon as possible and the next dose should be administered at the regularly scheduled time.
-This drug can be taken with or without food.
-The drug granules should not be chewed.
-This drug can be mixed with 3 to 4 ounces of applesauce, pudding, or yogurt and it also may be administered via a nasogastric tube or gastrostomy tube when necessary (e.g., coma, severe mucositis); the manufacturer product information should be consulted for administration instructions.

Storage Requirements:
-This drug should be stored at 25 degrees Celsius (77 Fahrenheit); excursions permitted to 15 to 30 degrees Celsius (59 to 86 Fahrenheit).

Preparation Techniques:
-Consult the manufacturer product information for preparation information.
-Discard any unused drug granules.

General:
-There are no apparent differences in clinical response between adults and pediatric patients with hereditary orotic aciduria treated with uridine; however, data are limited.
-Clinical studies did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently than younger subjects.
-This drug is not recommended for non-emergent treatment of adverse reactions associated with fluorouracil or capecitabine because it may diminish the efficacy of these drugs.
-The safety and efficacy of this drug initiated more than 96 hours following the end of fluorouracil or capecitabine administration have not been established.
-Animal studies show this drug diminishes hematological toxicity and damage to the intestinal mucosa caused by fluorouracil treatment.

Patient Advice:
-Take the full treatment course even if you feel well.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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