Triheptanoin Dosage
Medically reviewed by Drugs.com. Last updated on Feb 26, 2025.
Applies to the following strengths: 100%
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Functional Gastric Disorder
Recommended total daily dose (mL) = patients DCI (kcal) x target % dose of DCI / 8.3 kcal/mL
- Round to nearest whole number
- Divide total daily dose into at least 4 approximately equal individual doses
Dose Initiation/Titration:
Patients not currently taking a medium chain triglyceride (MCT) product:
- Initiate at approximately 10% DCI divided into at least 4 individual doses.
- Increase to recommended total daily dose over 2 to 3 weeks.
Patients switching from another MCT product:
- Discontinue previous MCT before therapy initiation.
- Initiate at last tolerated MCT dose divided into at least 4 individual doses.
- Increase total daily dosage by approximately 5% DCI every 2 to 3 days until target dosage is achieved.
Comments:
- Assess metabolic requirements by determining daily caloric intake (DCI) prior to dose calculations.
- Recommended target is 35% of DCI.
- Caloric value of this product is 8.3 kcal/mL.
Use: As a source of calories and fatty acid in patients with molecularly confirmed long-chain fatty acid oxidation disorders (LC-FAOD).
Usual Pediatric Dose for Functional Gastric Disorder
Recommended total daily dose (mL) = patients DCI (kcal) x target % dose of DCI / 8.3 kcal/mL
- Round to nearest whole number
- Divide total daily dose into at least 4 approximately equal individual doses
Dose Initiation/Titration:
Patients not currently taking a medium chain triglyceride (MCT) product:
- Initiate at approximately 10% DCI divided into at least 4 individual doses.
- Increase to recommended total daily dose over 2 to 3 weeks.
Patients switching from another MCT product:
- Discontinue previous MCT before therapy initiation.
- Initiate at last tolerated MCT dose divided into at least 4 individual doses.
- Increase total daily dosage by approximately 5% DCI every 2 to 3 days until target dosage is achieved.
Comments:
- Assess metabolic requirements by determining daily caloric intake (DCI) prior to dose calculations.
- Recommended target is 35% of DCI.
- Caloric value of this product is 8.3 kcal/mL.
- Neonates may require a higher fat intake and thus an increased dose of this product; consider current nutritional recommendations when dosing in this population.
Use: As a source of calories and fatty acid in patients with molecularly confirmed long-chain fatty acid oxidation disorders (LC-FAOD).
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dose Adjustments
Gastrointestinal Adverse Reactions:
- Consider dose reduction until symptoms resolve.
- If unable to achieve target dosage (up to 35% of daily caloric intake), maintain at maximum tolerated dose
Precautions
CONTRAINDICATIONS: None
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- Administer at mealtimes or with snacks or via a feeding tube.
- To avoid gastrointestinal upset, do not administer alone.
Reconstitution/preparation techniques: The manufacturer product information should be consulted.
Monitoring:
- Monitor total caloric intake during dose titration, especially if gastrointestinal adverse reactions occur; adjust all components of diet as needed.
More about triheptanoin
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- Drug class: oral nutritional supplements
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