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Triheptanoin Dosage

Medically reviewed by Drugs.com. Last updated on Sep 24, 2020.

Applies to the following strengths: 100%

Usual Adult Dose for Functional Gastric Disorder

Recommended total daily dose (mL) = patients DCI (kcal) x target % dose of DCI / 8.3 kcal/mL
-Round to nearest whole number
-Divide total daily dose into at least 4 approximately equal individual doses


Dose Initiation/Titration:

Patients not currently taking a medium chain triglyceride (MCT) product:
-Initiate at approximately 10% DCI divided into at least 4 individual doses.
-Increase to recommended total daily dose over 2 to 3 weeks.

Patients switching from another MCT product:
-Discontinue previous MCT before therapy initiation.
-Initiate at last tolerated MCT dose divided into at least 4 individual doses.
-Increase total daily dosage by approximately 5% DCI every 2 to 3 days until target dosage is achieved.


Comments:
-Assess metabolic requirements by determining daily caloric intake (DCI) prior to dose calculations.
-Recommended target is 35% of DCI.
-Caloric value of this product is 8.3 kcal/mL.

Use: As a source of calories and fatty acid in patients with molecularly confirmed long-chain fatty acid oxidation disorders (LC-FAOD).

Usual Pediatric Dose for Functional Gastric Disorder

Recommended total daily dose (mL) = patients DCI (kcal) x target % dose of DCI / 8.3 kcal/mL
-Round to nearest whole number
-Divide total daily dose into at least 4 approximately equal individual doses


Dose Initiation/Titration:

Patients not currently taking a medium chain triglyceride (MCT) product:
-Initiate at approximately 10% DCI divided into at least 4 individual doses.
-Increase to recommended total daily dose over 2 to 3 weeks.

Patients switching from another MCT product:
-Discontinue previous MCT before therapy initiation.
-Initiate at last tolerated MCT dose divided into at least 4 individual doses.
-Increase total daily dosage by approximately 5% DCI every 2 to 3 days until target dosage is achieved.


Comments:
-Assess metabolic requirements by determining daily caloric intake (DCI) prior to dose calculations.
-Recommended target is 35% of DCI.
-Caloric value of this product is 8.3 kcal/mL.
-Neonates may require a higher fat intake and thus an increased dose of this product; consider current nutritional recommendations when dosing in this population.

Use: As a source of calories and fatty acid in patients with molecularly confirmed long-chain fatty acid oxidation disorders (LC-FAOD).

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Gastrointestinal Adverse Reactions:
-Consider dose reduction until symptoms resolve.
-If unable to achieve target dosage (up to 35% of daily caloric intake), maintain at maximum tolerated dose

Precautions

CONTRAINDICATIONS: None

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Administer at mealtimes or with snacks or via a feeding tube.
-To avoid gastrointestinal upset, do not administer alone.

Reconstitution/preparation techniques: The manufacturer product information should be consulted.

Monitoring:
-Monitor total caloric intake during dose titration, especially if gastrointestinal adverse reactions occur; adjust all components of diet as needed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.