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Spy Agent Green Dosage

Generic name: INDOCYANINE GREEN 25mg; WATER 1mL in 1mL
Dosage form: kit

Medically reviewed by Drugs.com. Last updated on Apr 13, 2020.

Recommended Dose and Administration for Visualization of Vessels, Blood Flow and Tissue Perfusion

Dosing
Adults:
The recommended dose of SPY AGENT GREEN for a single image sequence is 1.25 mg to 5 mg of a 2.5 mg/mL solution.

For visualization of perfusion in extremities through the skin, the recommended dose is 3.75 mg to 10 mg of a 2.5 mg/mL solution.

Immediately flush with a 10 mL bolus of 0.9% Sodium Chloride, USP.

Pediatric patients:
The recommended dose for a single image sequence is 1.25 mg to 5 mg SPY AGENT GREEN of a 2.5 mg/mL solution. Lower doses may be administered in younger patients and in those with lower body weight. Adjust the amount and type of flush to avoid volume and/or sodium overload.

Additional doses may be administered to obtain imaging sequences during the procedure. Do not exceed the maximum total dose of 2 mg/kg.

Administration
Prior to the imaging procedure, draw up the desired dosage of SPY AGENT GREEN solution into appropriate syringes and prepare a 10 mL syringe of 0.9% Sodium Chloride, USP.

Administer via a central or peripheral venous line using a three-way stopcock attached to an injection port on the infusion line.

Inject the prepared SPY AGENT GREEN into the line as a tight bolus. Immediately switch the access on the stopcock and inject the prepared flush.

Imaging Instructions for Visualization of Vessels, Blood Flow and Tissue Perfusion
SPY AGENT GREEN may be used with either the SPY ® Elite or PINPOINT ® Fluorescence Imaging Systems or with a FDA cleared or approved imaging device that is specifically intended for fluorescence imaging with indocyanine green.

A fluorescence response should be visible in blood vessels within 5 to 15 seconds after injection.

Recommended Dose and Administration for Visualization of Extrahepatic Biliary Ducts

Dosing and Administration
The recommended single dose of SPY AGENT GREEN for adults and pediatric patients aged 12 to 17 years is 2.5 mg of a 2.5 mg/mL solution administered intravenously as a single dose at least 45 minutes prior to surgery. Additional doses may be administered to obtain imaging sequences during the procedure.
Do not exceed a total dose of 2 mg/kg.

Imaging Instructions for Visualization of Extrahepatic Biliary Ducts
SPY AGENT GREEN may be used with the PINPOINT ® Fluorescence Imaging System or with a FDA cleared or approved imaging device that is specifically intended for fluorescence imaging with indocyanine green.

Fluorescence is visible in the biliary tree within 45 minutes after injection.

Recommended Dose and Administration for Visualization of Lymph Nodes and Lymphatic Vessels During Lymphatic Mapping for Cervical and Uterine Tumors

Dosing and Administration

The recommended single dose of SPY AGENT GREEN is 5 mg of a 1.25 mg/mL solution (four 1 mL injections administered interstitially into the cervix, at the three o’ clock and the nine o’clock positions with a superficial (1 mm to 3 mm) and a deep (1 cm to 3 cm) injection at each position).

Imaging Instructions for Visualization of Lymph Nodes and Lymphatic Vessels During Lymphatic Mapping

SPY AGENT GREEN may be used with the PINPOINT ® Fluorescence Imaging System or with a FDA cleared or approved imaging device that is specifically intended for fluorescence imaging with indocyanine green.

Fluorescent lymphatic vessels and lymph nodes should begin to be visible within 1 minute after injection.

Reconstitution Instructions

General

  • Prepare SPY AGENT GREEN under sterile conditions prior to surgery.
  • Inspect the reconstituted solution for particulate matter, the reconstituted solution should be a clear, green solution.
  • Use the prepared solution within 6 hours.
  • Discard any unused product.

Visualization of Vessels, Blood Flow, and Tissue Perfusion and Visualization of Extrahepatic Biliary Ducts

  • Dissolve SPY AGENT GREEN with 10 mL Sterile Water for Injection, USP to form a concentration of 2.5 mg indocyanine green/mL.

Visualization of Lymph Nodes and Lymphatic Vessels During Lymphatic Mapping

  • Dissolve SPY AGENT GREEN with 20 mL Sterile Water for Injection, USP to form a concentration of 1.25 mg indocyanine green/mL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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