Peramivir Dosage

Usual Adult Dose for Influenza

600 mg single IV infusion over 15 to 30 minutes

Comments:
-Dilute appropriate dose of drug solution in 0.9% or 0.45% sodium chloride, 5% dextrose, or lactated Ringer's to a maximum volume of 100 mL.
-Administer immediately or store in refrigerator (2 to 8C or 36 to 46F) for up to 24 hours. Allow solution to reach room temperature before administering.
-Do not mix or co-infuse with other IV medications.

Use: Treatment of acute, uncomplicated influenza in adults who have been symptomatic for 2 days or less

Renal Dose Adjustments

CrCl 50 mL/min or greater: No dose adjustment necessary
CrCl 30 to 49 mL/min: 200 mg IV once
CrCl 10 to 29 mL/min: 100 mg IV once

Liver Dose Adjustments

No adjustment recommended

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Administer post hemodialysis based on renal function.