Peramivir Dosage

Medically reviewed by Drugs.com. Last updated on May 20, 2022.

Applies to the following strengths: 10 mg/mL

Usual Adult Dose for Influenza

600 mg IV once as a single dose

Use: For the treatment of acute uncomplicated influenza in patients symptomatic no more than 2 days

Usual Pediatric Dose for Influenza

6 months to 12 years: 12 mg/kg IV once as a single dose

Maximum dose: 600 mg/dose

13 years or older: 600 mg IV once as a single dose

Use: For the treatment of acute uncomplicated influenza in patients symptomatic no more than 2 days

Renal Dose Adjustments

Adults and adolescents 13 years or older:

CrCl at least 50 mL/min: No adjustment recommended.
CrCl 30 to 49 mL/min: 200 mg IV once
CrCl 10 to 29 mL/min: 100 mg IV once

Pediatric patients 2 to 12 years of age:

CrCl at least 50 mL/min: No adjustment recommended.
CrCl 30 to 49 mL/min: 4 mg/kg IV once
Maximum dose: 200 mg/dose
CrCl 10 to 29 mL/min: 2 mg/kg IV once
Maximum dose: 100 mg/dose

Pediatric patients 6 months to less than 2 years of age:

CrCl less than 50 mL/min: Data not available

Comments:

CrCl calculated using the Cockcroft-Gault formula.
The pharmacokinetics (PKs) of this drug have not been studied in pediatric subjects with renal dysfunction; since the PKs in pediatric subjects with normal renal function are comparable to those in adults, the same proportional dose reduction is recommended in pediatric patients at least 2 years of age with renal dysfunction.
Due to developmental immaturity of renal function in patients younger than 2 years, a recommendation for dose reduction cannot be made for patients 6 months to less than 2 years of age with CrCl less than 50 mL/min.

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
Known serious hypersensitivity or anaphylaxis to the active component or any of the ingredients

Safety and efficacy have not been established in patients younger than 6 months.

Consult WARNINGS section for additional precautions.

Dialysis

Hemodialysis: Dose should be adjusted based on renal function and administered after dialysis.

Other Comments

Administration advice:

Administer within 2 days of onset of influenza symptoms.
Administer via IV infusion for 15 to 30 minutes.
If diluted solution is refrigerated, allow it to reach room temperature then administer immediately; discard unused diluted solution after 24 hours.

Storage requirements:

Vials: Store in original containers at 20C to 25C (68F to 77F); excursions permitted to 15C to 30C (59F to 86F).
Diluted solution: If not administered immediately, store refrigerated (2C to 8C [36F to 46F]) for up to 24 hours.

Reconstitution/preparation techniques:

This drug must be diluted before infusion; the final concentration of diluted solution for administration should be between 1 and 6 mg/mL.
Maximum infusion volume:
Age 6 months to 1 year: 25 mL
Age 1 year and older, weight 5 to less than 10 kg: 25 mL
Age 1 year and older, weight 10 to less than 15 kg: 50 mL
Age 1 year and older, weight 15 to less than 20 kg: 75 mL
Age 1 year and older, weight at least 20 kg: 100 mL
The manufacturer product information should be consulted.

IV compatibility:

Compatible: 0.9% or 0.45% sodium chloride, 5% dextrose, lactated Ringers; materials commonly used for administration (e.g., polyvinylchloride [PVC] bags, PVC-free bags, polypropylene syringes, polyethylene tubing)
Do not mix or co-infuse with other IV agents.

General (limitations of use):

Efficacy based on clinical trials of naturally-occurring influenza in which the infections were mostly due to influenza A virus; limited number enrolled who were infected with influenza B virus.
As influenza viruses change over time, resistant or more virulent mutations may emerge and decrease the efficacy of antiviral drugs; available information on influenza drug susceptibility patterns and treatment effects should be considered when deciding whether to use this drug.
Efficacy not established in patients with serious influenza requiring hospitalization.

Monitoring:

Psychiatric: For signs of abnormal behavior in patients with influenza

Patient advice:

Seek medical attention at once if an allergic-like reaction occurs/is suspected.
After receiving this drug, contact physician if signs of abnormal behavior occur.