Peramivir Dosage

Medically reviewed on May 30, 2018.

Usual Adult Dose for Influenza

600 mg IV once as a single dose

Use: For the treatment of acute uncomplicated influenza in patients symptomatic no more than 2 days

Usual Pediatric Dose for Influenza

2 to 12 years: 12 mg/kg IV once as a single dose
-Maximum dose: 600 mg/dose
13 years or older: 600 mg IV once as a single dose

Use: For the treatment of acute uncomplicated influenza in patients symptomatic no more than 2 days

Renal Dose Adjustments

Adults and adolescents (13 years or older):
-CrCl at least 50 mL/min: No adjustment recommended.
-CrCl 30 to 49 mL/min: 200 mg IV once
-CrCl 10 to 29 mL/min: 100 mg IV once

Pediatric patients (2 to 12 years):
-CrCl at least 50 mL/min: No adjustment recommended.
-CrCl 30 to 49 mL/min: 4 mg/kg IV once
-CrCl 10 to 29 mL/min: 2 mg/kg IV once

Comments:
-CrCl calculated using the Cockcroft-Gault formula.
-The manufacturer product information should be consulted regarding maximum dose in pediatric patients (2 to 12 years).

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
Known serious hypersensitivity or anaphylaxis to the active component or any of the ingredients

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Dialysis

Hemodialysis: Dose should be adjusted based on renal function and administered after dialysis.

Other Comments

Administration advice:
-Administer within 2 days of onset of influenza symptoms.
-Administer via IV infusion for 15 to 30 minutes.
-If diluted solution is refrigerated, allow it to reach room temperature then administer immediately; discard unused diluted solution after 24 hours.

Storage requirements:
-Vials: Store in original containers at 20C to 25C (68F to 77F); excursions permitted to 15C to 30C (59F to 86F).
-Diluted solution: If not administered immediately, store refrigerated (2C to 8C [36F to 46F) for up to 24 hours.

Reconstitution/preparation techniques:
-This drug must be diluted before infusion.
-The manufacturer product information should be consulted.

IV compatibility:
-Compatible: 0.9% or 0.45% sodium chloride, 5% dextrose, lactated Ringers; materials commonly used for administration (e.g., polyvinylchloride [PVC] bags, PVC-free bags, polypropylene syringes, polyethylene tubing)
-Do not mix or co-infuse with other IV agents.

General (limitations of use):
-Efficacy based on clinical trials of naturally-occurring influenza in which the infections were mostly due to influenza A virus; limited number enrolled who were infected with influenza B virus.
-As influenza viruses change over time, resistant or more virulent mutations may emerge and decrease the efficacy of antiviral drugs; available influenza drug susceptibility patterns and treatment effects should be considered when deciding whether to use this drug.
-Efficacy not established in patients with serious influenza requiring hospitalization.

Monitoring:
-Psychiatric: For signs of abnormal behavior in patients with influenza

Patient advice:
-Seek medical attention at once if an allergic-like reaction occurs/is suspected.
-After receiving this drug, contact physician if signs of abnormal behavior occur.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer