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Peramivir Side Effects

For the Consumer

Applies to peramivir: intravenous solution, solution iv (infusion)

Along with its needed effects, peramivir may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking peramivir:

Less common
Incidence not known
  • Blistering, peeling, or loosening of the skin
  • chills
  • confusion as to time, place, or person
  • cough
  • diarrhea
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • hives, itching, skin rash
  • holding false beliefs that cannot be changed by fact
  • joint or muscle pain
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • seeing, hearing, or feeling things that are not there
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • tightness in the chest
  • unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness

Some side effects of peramivir may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Blurred vision
  • constipation
  • difficulty having a bowel movement
  • headache
  • nervousness
  • pounding in the ears
  • redness of the eardrum
  • slow or fast heartbeat
  • trouble sleeping
  • vomiting

For Healthcare Professionals

Applies to peramivir: intravenous solution

Hematologic

Decreased neutrophils (less than 1 x 10[9]/L) was reported in 8% of patients.[Ref]

Common (1% to 10%): Decreased neutrophils[Ref]

Gastrointestinal

Vomiting was reported in 3% of pediatric patients; this side effect was not reported in adults.[Ref]

Common (1% to 10%): Diarrhea, constipation
Frequency not reported: Vomiting[Ref]

Dermatologic

Rare (less than 0.1%): Serious skin reactions (including erythema multiforme)
Postmarketing reports: Stevens-Johnson syndrome, exfoliative dermatitis, rash[Ref]

Hypersensitivity

Postmarketing reports: Anaphylactic/anaphylactoid reactions[Ref]

Metabolic

Common (1% to 10%): Elevated serum glucose[Ref]

Elevated serum glucose (greater than 160 mg/dL) was reported in 5% of patients.[Ref]

Musculoskeletal

Elevated creatine phosphokinase (at least 6 times the upper limit of normal [6 x ULN]) was reported in 4% of patients.[Ref]

Common (1% to 10%): Elevated creatine phosphokinase[Ref]

Hepatic

Common (1% to 10%): Increased ALT, increased AST[Ref]

Increased ALT (greater than 2.5 x ULN) was reported in 3% of patients.[Ref]

Psychiatric

Common (1% to 10%): Insomnia
Postmarketing reports: Delirium, abnormal behavior, hallucination[Ref]

Cardiovascular

Common (1% to 10%): Hypertension[Ref]

Genitourinary

Frequency not reported: Proteinuria[Ref]

Proteinuria (by dipstick analysis) was reported in 3% of pediatric patients; this side effect was not reported in adults.[Ref]

Other

Frequency not reported: Fever, tympanic membrane erythema[Ref]

Fever and tympanic membrane erythema were reported in 2% (each) of pediatric patients; these side effects were not reported in adults.[Ref]

References

1. "Product Information. Rapivab (peramivir)." BioCryst Pharmaceuticals Inc, Durham, NC.

Some side effects of peramivir may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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