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Nitric Oxide Dosage

Medically reviewed on December 1, 2017.

Applies to the following strengths: 100 ppm; 800 ppm

Usual Pediatric Dose for:

Additional dosage information:

Usual Pediatric Dose for Respiratory Failure

Recommended dose: 20 ppm
Duration of therapy: 14 days or until the underlying oxygen desaturation has resolved
Weaning off: Down-titrate in several steps, pausing several hours at each step to monitor for hypoxemia

Comments:
-Doses above 20 ppm are not recommended
-Avoid abrupt discontinuation

Use(s): To improve oxygenation and reduce the need for extracorporeal membrane oxygenation in term and near term (over 34 weeks gestation) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in conjunction with ventilatory support and other appropriate agents

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
-Neonates dependent on right-to-left shunting of blood

Safety and efficacy have not been established in patients other than term and near term neonates.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Users of Nitric Oxide Delivery Systems must complete a comprehensive periodic training program provided by the delivery system and drug manufacturers.
-Avoid abrupt discontinuation.

Storage requirements:
-Store at controlled room temperature
-Protect cylinders from shocks, falls, oxidizing and flammable materials, moisture, and sources of heat or ignition.

Monitoring:
-Measure methemoglobin within 4 to 8 hours of treatment initiation and periodically throughout treatment.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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