Skip to main content


Generic name: alpha 1-proteinase inhibitorAL-fa-1-PRO-tee-nase-in-HIB-i-tor ]
Drug class: Miscellaneous respiratory agents

Medically reviewed by Philip Thornton, DipPharm. Last updated on Nov 6, 2023.

What is Glassia?

Glassia contains alpha 1-proteinase inhibitor, a protein, also called alpha 1-antitrypsin. This protein occurs naturally in the body and is important for preventing the breakdown of tissues in the lungs.

In people who lack the alpha 1-antitrypsin protein, breakdown of lung tissues can lead to emphysema (damage to the air sacs in the lungs).

Glassia is used to treat alpha 1-antitrypsin deficiency in people who have symptoms of emphysema.

Alpha 1-antitrypsin deficiency is a genetic (inherited) disorder and Glassia will not cure alpha 1-antitrypsin deficiency, and may not slow the progression of emphysema.


You should not use Glassia if you have ever had an allergic reaction to alpha 1-proteinase inhibitor, or if you have an IgA (immunoglobulin A) deficiency or antibody against IgA.

Call your doctor at once if you have a serious side effect such as fever, chills, body aches, flu symptoms, mouth sores, pain or burning when you urinate, wheezing, chest pain or tightness, trouble breathing, or vision changes. Glassia is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

Before taking this medicine

You should not use Glassia if:

To make sure Glassia is safe for you, tell your doctor if you have:

Tell your doctor if you are pregnant or breastfeeding.

Glassia is not approved for use by anyone younger than 18 years old.

Glassia is made from donated human plasma and may contain viruses or other infectious agents. Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Ask your doctor about any possible risk.

How should I use Glassia?

Use Glassia exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Glassia is injected into a vein, usually once per week.

Your first dose may be given in a medical setting where any serious side effects can be quickly treated.

Ask your doctor or pharmacist if you don't understand how to use an injection.

Glassia is a liquid form of alpha 1-proteinase inhibitor that is not mixed with a diluent.

Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors, or has particles in it.

Do not reuse a needle or syringe. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.

Doses are based on weight. Your dose may change if you gain or lose weight.

Store Glassia in the original carton in the refrigerator. Take the medicine out of the refrigerator and let it reach room temperature before preparing your dose.

Once Glassia has reached room temperature, you must use it within 1 month. Do not return it to a refrigerator.

Do not freeze Glassia, and do not use it past the expiration date on the medicine label.

Throw away a vial (bottle) after one use, even if there is still medicine left inside.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Glassia?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Glassia side effects

Get emergency medical help if you have signs of an allergic reaction to Glassia: hives, rash; confusion, feeling light-headed; fast heartbeats, chest tightness, difficult breathing; swelling of your face, lips, tongue, or throat.

Your doctor may also prescribe epinephrine (Epi-Pen) to keep with you in case you ever have an allergic reaction to Glassia.

Stop using Glassia and call your doctor at once if you have:

You may feel faint during the injection. You may need to rest for a short time afterward.

Common Glassia side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Glassia?

Other drugs may interact with alpha 1-proteinase inhibitor, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Glassia only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.