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Levocarnitine Dosage

Applies to the following strength(s): 200 mg/mL ; 250 mg ; 100 mg/mL ; 330 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Carnitine Deficiency

Tablets:
> 18 years:
990 mg 2 to 3 times a day.

Oral Solution:
> 18 years:
1 to 3 g/day. Start dosing with 1 g/day. Doses should be spaced evenly throughout the day (every 3 or 4 hours).

Injection:
50 mg/kg given as slow IV bolus injection (over 2 to 3 minutes) or by infusion. Often a loading dose is given in patients with severe metabolic acidosis followed by an equivalent dose over the next 24 hours. It should be administered every 3 to 4 hours and never less than every 6 hours. All subsequent doses are recommended to be in the range of 50 mg/kg/day.

Usual Pediatric Dose for Carnitine Deficiency

Tablets:
> 1 month to 18 years:
50 to 100 mg/kg/day in divided doses. Maximum dose: 3 g/day.

Solution:
> 1 month to 18 years:
50 to 100 mg/kg/day. Doses should be spaced evenly throughout the day (every 3 or 4 hours). Start dosing at 50 mg/kg/day. Maximum dose: 3 g/day.

Injection:
50 mg/kg given as a slow IV bolus injection (over 2 to 3 minutes) or by infusion. Often a loading dose is given in patients with severe metabolic acidosis followed by an equivalent dose over the next 24 hours. It should be administered every 3 to 4 hours and never less than every 6 hours. All subsequent doses are recommended to be in the range of 50 mg/kg/day.

Renal Dose Adjustments

Oral levocarnitine has not been evaluated for safety and efficacy in patients with renal insufficiency. Chronic administration of high doses of oral levocarnitine in these patients, especially patients with ESRD (end stage renal disease) or severely compromised renal function, may result in accumulation of several potentially toxic metabolites.

Liver Dose Adjustments

Data not available

Precautions

Levocarnitine oral solution may be consumed alone or with drinks or liquid food for taste. It should be consumed slowly to reduce gastrointestinal reactions.

Monitoring should include periodic blood chemistries, vital signs, plasma carnitine concentrations and overall clinical conditions.

Dialysis

Levocarnitine injectable is approved by the FDA for the treatment of carnitine deficiency in patients with end stage renal disease who are undergoing hemodialysis. Levocarnitine is moderately removed by hemodialysis. The elimination half-life of levocarnitine on and off dialysis averages 2.34 and 1.76 to 1.98 hours, respectively. Plasma concentration of levocarnitine reductions by 49.27% and 44.56% of total and free carnitine, respectively, after 4-hour dialysis.

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