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Kionex Dosage

Generic name: SODIUM POLYSTYRENE SULFONATE 4.1meq in 1g
Dosage form: oral / rectal suspension
Drug class: Cation exchange resins

Medically reviewed by Last updated on Aug 7, 2023.

General Information

Administer Kionex at least 3 hours before or 3 hours after other oral medications. Patients with gastroparesis may require a 6 hour separation [see Warnings and Precautions (5.5) and Drug Interaction (7)]

Recommended Dosage

The intensity and duration of therapy depend upon the severity and resistance of hyperkalemia.


The average total daily adult dose of Kionex is 15 g to 60 g, administered as a 15-g dose (four level teaspoons), one to four times daily.


The average adult dose is 30 g to 50 g every six hours.

Preparation and Administration

Prepare suspension fresh and use within 24 hours.

Do not heat Kionex as it could alter the exchange properties of the resin.

One level teaspoon contains approximately 3.5 g of Kionex and 15 mEq of sodium.

Oral Suspension

Suspend each dose in a small quantity of water or syrup, approximately 3 to 4 mL of liquid per gram of resin. Administer with patient in an upright position [see Warnings and Precautions (5.4)].


After an initial cleansing enema, insert a soft, large size (French 28) rubber tube into the rectum for a distance of about 20 cm, with the tip well into the sigmoid colon, and tape in place.

Administer as a warm (body temperature) emulsion in 100 mL of aqueous vehicle and flush with 50 to 100 ml of fluid. A somewhat thicker suspension may be used, but do not form a paste.

Agitate the emulsion gently during administration. The resin should be retained for as long as possible and follow by a cleansing enema with a nonsodium containing solution. Ensure an adequate volume of cleansing solution (up to 2 liters) is utilized.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.