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Kinevac Dosage

Generic name: Sincalide 5ug in 5mL
Dosage form: injection, powder, lyophilized, for solution

Medically reviewed by Drugs.com. Last updated on Dec 1, 2018.

2.1 Recommended Dosage and Administration Instructions

The recommended dosage and administration of Kinevac by indication is shown in Table 1. For preparation instructions see Dosage and Administration (2.2).

Table 1: Recommended Adult Dosage and Administration of Kinevac by Treatment Indication

Indication Recommended Adult Dosage and Administration of KINEVAC
To stimulate contraction of the gallbladder

Kinevac 0.02 mcg/kg as a single dose over 30 to 60 seconds via intravenous injection. If satisfactory contraction does not occur in 15 minutes, administer a dose of 0.04 mcg/kg over 30 to 60 seconds.

Alternatively, Consider an Intravenous Infusion to Reduce Gastrointestinal Adverse Reactions [see Warnings and Precautions (5.3)]: 0.12 mcg/kg diluted in 100 mL of 0.9% Sodium Chloride Injection USP and infused over 50 minutes at a rate of 2 mL per minute.

To stimulate pancreatic secretion in combination with secretin for injection

Secretin for Injection: 0.25 units/kg as intravenous infusion over 60 minutes

Kinevac: 30 minutes after initiation of secretin infusion, administer Kinevac 0.02 mcg/kg diluted in 30 mL of 0.9% Sodium Chloride Injection USP and infused over 30 minutes at a rate of 1 mL per minute.

To accelerate the transit of a barium meal through the small intestine

After the barium meal is beyond the proximal jejunum, administer Kinevac 0.04 mcg/kg over 30 to 60 seconds via intravenous injection.

If satisfactory transit of the barium meal has not occurred in 30 minutes, administer a second dose of 0.04 mcg/kg over 30 to 60 seconds.

Alternatively, Consider an Intravenous Infusion to Reduce Gastrointestinal Adverse Reactions [see Warnings and Precautions (5.3)]: 0.12 mcg/kg diluted in 100 mL 0.9% Sodium Chloride Injection USP and infused over 30 minutes.

2.2 Preparation Instructions

For Intravenous Injection

  • Reconstitute Kinevac aseptically by adding 5 mL of Sterile Water for Injection USP to the vial.
  • Inspect the reconstituted solution visually for particulate matter and discoloration after reconstitution and prior to administration.
  • Withdraw the prescribed dose of the reconstituted solution from the vial and administer as an intravenous injection over 30 to 60 seconds, as shown in Table 1. Discard the unused portion.
  • Store the reconstituted solution at room temperature. Discard after 8 hours.
  • For single use only; discard unused portion.

For Intravenous Infusion

  • Reconstitute Kinevac aseptically by adding 5 mL of Sterile Water for Injection USP to the vial.
  • After reconstitution, withdraw the prescribed dose of the solution from the vial. Discard unused portion.
  • Dilute the reconstituted solution in 30 mL or 100 mL of 0.9% Sodium Chloride Injection USP, depending on the indication, as described in Table 1.
  • Inspect the Kinevac solutions visually for particulate matter and discoloration after reconstitution, dilution and prior to administration.
  • Store the diluted solution at room temperature. Discard after 1 hour.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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