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Kinevac Side Effects

Generic name: sincalide

Medically reviewed by Last updated on Apr 19, 2022.

Note: This document contains side effect information about sincalide. Some of the dosage forms listed on this page may not apply to the brand name Kinevac.

For the Consumer

Applies to sincalide: intravenous powder for solution

Side effects requiring immediate medical attention

Along with its needed effects, sincalide (the active ingredient contained in Kinevac) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking sincalide:

Less common

  • Blurred vision
  • confusion
  • cough
  • difficulty swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • headache
  • hives, itching, skin rash
  • loss of consciousness
  • nervousness
  • numbness of the face, lips, and eyes
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seizures
  • slow or fast heartbeat
  • stomach cramping
  • sweating
  • tightness of the chest
  • unusual tiredness or weakness

Side effects not requiring immediate medical attention

Some side effects of sincalide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Nausea
  • stomach discomfort or pain

Less common

  • Diarrhea
  • feeling of warmth
  • increased sweating
  • redness of the face, neck, arms, and occasionally, upper chest
  • sneezing
  • urge to defecate
  • vomiting

For Healthcare Professionals

Applies to sincalide: injectable powder for injection, intravenous powder for injection


Gastrointestinal side effects have included abdominal discomfort or pain and nausea. Rapid IV injection of 0.04 mcg sincalide (the active ingredient contained in Kinevac) per kg would be expected to cause transient abdominal cramping. These side effects are usually manifestations of the physiologic action of the drug, including delayed gastric emptying and increased intestinal motility. These side effects occurred in approximately 20% of patients but they are not to be construed as necessarily indicating an abnormality of the biliary tract unless there is other clinical or radiologic evidence of disease.[Ref]


Reactions to sincalide (the active ingredient contained in Kinevac) are usually mild and of short duration. Adverse reactions including vomiting, flushing, sweating, rash, hypotension, hypertension, shortness of breath, urge to defecate, headache, diarrhea, sneezing, and numbness were less than 1%. Dizziness was reported in approximately 2% of patients. These manifestations are usually attenuated by a slower injection rate.[Ref]


1. "Product Information. Kinevac (sincalide)." Bristol-Myers Squibb (2010):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.