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Gadavist Dosage

Generic name: GADOBUTROL 604.72mg in 1mL
Dosage form: injection
Drug class: Magnetic resonance imaging contrast media

Medically reviewed by Drugs.com. Last updated on Jan 30, 2024.

Recommended Dose

The recommended dose of Gadavist for adult and pediatric patients (including term neonates) is 0.1 mL/kg body weight (0.1 mmol/kg). Refer to Table 1 to determine the volume to be administered.

Table 1: Volume of Gadavist Injection by Body Weight*

Body Weight (kg)

Volume to be Administered (mL)

2.5

0.25

5

0.5

10

1

15

1.5

20

2

25

2.5

30

3

35

3.5

40

4

45

4.5

50

5

60

6

70

7

80

8

90

9

100

10

110

11

120

12

130

13

140

14

* For Cardiac MRI, the dose is divided into 2 separate, equal injections

Administration Guidelines

•
Gadavist is formulated at a higher concentration (1 mmol/mL) compared to certain other gadolinium based contrast agents, resulting in a lower volume of administration. Use Table 1 to determine the volume to be administered.
•
Use sterile technique when preparing and administering Gadavist.

MRI of the Central Nervous System

•
Administer Gadavist as an intravenous injection, manually or by power injector, at a flow rate of approximately 2 mL/second.
•
Follow Gadavist injection with flush of 0.9% Sodium Chloride Injection, USP to ensure complete administration of the contrast.
•
Post contrast MRI can commence immediately following contrast administration.

MRI of the Breast

•
Administer Gadavist as an intravenous bolus by power injector, followed by a flush of 0.9% Sodium Chloride Injection, USP to ensure complete administration of the contrast.
•
Start image acquisition following contrast administration and then repeat sequentially to determine peak intensity and wash-out.

MR Angiography

Image acquisition should coincide with peak arterial concentration, which varies among patients.

Adults
•
Administer Gadavist by power injector, at a flow rate of approximately 1.5 mL/second, followed by a 30 mL flush of 0.9% Sodium Chloride Injection, USP at the same rate to ensure complete administration of the contrast.
Pediatric patients
•
Administer Gadavist by power injector or manually, followed by a flush of 0.9% Sodium Chloride Injection, USP to ensure complete administration of the contrast.

​Cardiac MRI

•
​Administer Gadavist through a separate intravenous line in the contralateral arm if concomitantly providing a continuous infusion of a pharmacologic stress agent.
•
​Administer Gadavist as two (2) separate bolus injections: 0.05 mL/kg (0.05 mmol/kg) body weight at peak pharmacologic stress followed by 0.05 mL/kg (0.05 mmol/kg) body weight at rest.
•
​Administer Gadavist via a power injector at a flow rate of approximately 4 mL/second and follow each injection with a flush of 20 mL of 0.9% Sodium Chloride Injection, USP at the same flow rate.

Drug Handling

•
Visually inspect Gadavist for particulate matter and discoloration prior to administration. Do not use the solution if it is discolored, if particulate matter is present or if the container appears damaged.
•
Do not mix Gadavist with other medications and do not administer Gadavist in the same intravenous line simultaneously with other medications because of the potential for chemical incompatibility.
•
Instructions of the device manufacturer must be followed.

Imaging Bulk Package Preparation Instruction

Gadavist Imaging Bulk Package (IBP) is a container of a sterile preparation for parenteral use that contains many single doses of gadobutrol for use with a medical imaging device. Gadavist Imaging Bulk Package is for intravenous use and not for direct infusion. Gadavist Imaging Bulk Package is for use only with an automated contrast injection system, contrast management system, or contrast media transfer set approved or cleared for use with this contrast agent in this Imaging Bulk Package. Please see drug and device labeling for information on devices indicated for use with this Imaging Bulk Package and techniques to help assure safe use.

1.
The Gadavist Imaging Bulk Package is to be used only in a room designated for radiological procedures that involve intravascular administration of a contrast agent.
2.
Utilize aseptic technique for penetrating the container closure of the Gadavist Imaging Bulk Package and transferring Gadavist injection.
3.
The container closure must be penetrated only one time with a suitable sterile component of the automated contrast injection system, contrast management system, or contrast media transfer set (e.g. transfer spike) approved or cleared for use with this contrast agent in this Imaging Bulk Package.
4.
Once the Gadavist Imaging Bulk Package is punctured, do not remove it from the work area during the entire period of use. Storage temperature of Gadavist Imaging Bulk Package after the closure has been entered is 20°C to 25°C (68°F to 77°F).
5.
A maximum use time of 24 hours from initial puncture is permitted to complete fluid transfer. Discard any unused Gadavist injection 24 hours after initial puncture of the Imaging Bulk Package.
6.
After the container closure is punctured, if the integrity of the Imaging Bulk Package and the delivery system cannot be assured through direct continuous supervision, the Imaging Bulk Package and all associated disposables for the automated contrast injection system, contrast management system, or contrast media transfer set (e.g. transfer spike) should be discarded.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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