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Gadavist Dosage

Generic name: GADOBUTROL 604.72mg in 1mL
Dosage form: injection
Drug class: Magnetic resonance imaging contrast media

Medically reviewed by Drugs.com. Last updated on Jul 23, 2024.

Recommended Dose

The recommended dose of Gadavist for adult and pediatric patients (including term neonates) is 0.1 mL/kg body weight (0.1 mmol/kg). Refer to Table 1 to determine the volume to be administered.

Table 1: Volume of Gadavist Injection by Body Weight*

Body Weight (kg)

Volume to be Administered (mL)

2.5

0.25

5

0.5

10

1

15

1.5

20

2

25

2.5

30

3

35

3.5

40

4

45

4.5

50

5

60

6

70

7

80

8

90

9

100

10

110

11

120

12

130

13

140

14

*for Cardiac MRI, the dose is divided into 2 separate, equal injections

Administration Guidelines

•
Gadavist is formulated at a higher concentration (1 mmol/mL) compared to certain other gadolinium based contrast agents, resulting in a lower volume of administration. Use Table 1 to determine the volume to be administered.
•
Use sterile technique when preparing and administering Gadavist.

MRI of the Central Nervous System

•
​Administer Gadavist as an intravenous injection, manually or by power injector, at a flow rate of approximately 2 mL/second.
•
​Follow Gadavist injection with a normal saline flush to ensure complete administration of the contrast.
•
​Post contrast MRI can commence immediately following contrast administration.

MRI of the Breast

•
​Administer Gadavist as an intravenous bolus by power injector, followed by a normal saline flush to ensure complete administration of the contrast.
•
​Start image acquisition following contrast administration and then repeat sequentially to determine peak intensity and wash-out.

MR Angiography

​Image acquisition should coincide with peak arterial concentration, which varies among patients.

​Adults
•
​Administer Gadavist by power injector, at a flow rate of approximately 1.5 mL/second, followed by a 30 mL normal saline flush at the same rate to ensure complete administration of the contrast.
​Pediatric patients
•
​Administer Gadavist by power injector or manually, followed by a normal saline flush to ensure complete administration of the contrast.

Cardiac MRI

•
Administer Gadavist through a separate intravenous line in the contralateral arm if concomitantly providing a continuous infusion of a pharmacologic stress agent.
•
Administer Gadavist as two (2) separate bolus injections: 0.05 mL/kg (0.05 mmol/kg) body weight at peak pharmacologic stress followed by 0.05 mL/kg (0.05 mmol/kg) body weight at rest.
•
Administer Gadavist via a power injector at a flow rate of approximately 4 mL/second and follow each injection with a normal saline flush of 20 mL at the same flow rate.

Drug Handling

•
Visually inspect Gadavist for particulate matter and discoloration prior to administration. Do not use the solution if it is discolored, if particulate matter is present or if the container appears damaged.
•
Do not mix Gadavist with other medications and do not administer Gadavist in the same intravenous line simultaneously with other medications because of the potential for chemical incompatibility.

Vials

•
Draw Gadavist into the syringe immediately before use.
•
Do not pierce the rubber stopper more than once. Discard any unused vial contents.

Pre-filled syringes

•
Remove the tip cap from the pre-filled syringe immediately before use. Discard any unused syringe contents.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer