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Ferriprox Oral Solution Dosage

Generic name: DEFERIPRONE 100mg in 1mL
Dosage form: oral solution

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Medically reviewed by Drugs.com. Last updated on Feb 11, 2020.

Recommended Dosage

Starting Dose

The recommended initial dose of FERRIPROX is 25 mg/kg actual body weight, orally, three times per day for a total of 75 mg/kg/day. Round dose to the nearest 2.5 mL.

Table 1a: Volume of 100 mg/mL oral solution (rounded to the nearest 2.5 mL) required to achieve a 25 mg/kg dose for administration three times a day.
Body Weight (kg) Dose (mg) mL of oral solution
20 500 5
30 750 7.5
40 1,000 10
50 1,250 12.5
60 1,500 15
70 1,750 17.5
80 2,000 20
90 2,250 22.5

Dose Adjustments

Tailor dose adjustments to the individual patient’s response and therapeutic goals (maintenance or reduction of body iron burden). The maximum dose is 33 mg/kg actual body weight, three times per day for a total of 99 mg/kg/day.

Table 1b: Volume of 100 mg/mL oral solution (rounded to the nearest 2.5 mL) required to achieve a 33 mg/kg dose for administration three times a day.
Body Weight (kg) Dose (mg) mL of oral solution
20 660 7.5
30 990 10
40 1,320 12.5
50 1,650 17.5
60 1,980 20
70 2,310 22.5
80 2,640 27.5
90 2,970 30

Monitor serum ferritin concentration every two to three months to assess the effect of FERRIPROX on body iron stores. If the serum ferritin is consistently below 500 mcg/L, consider temporarily interrupting FERRIPROX therapy until serum ferritin rises above 500 mcg/L.

Dosage Modification for Drug Interactions

Allow at least a 4-hour interval between administration of FERRIPROX and other drugs or supplements containing polyvalent cations such as iron, aluminum, or zinc [see Drug Interactions (7.2), Clinical Pharmacology (12.3)].

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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