Ferriprox Oral Solution Dosage
Medically reviewed by Drugs.com. Last updated on Nov 30, 2021.
Generic name: DEFERIPRONE 100mg in 1mL
Dosage form: oral solution
Important Dosage and Administration Information
Monitoring for Safety
Due to the risk of agranulocytosis, monitor ANC before and during FERRIPROX therapy.
Test ANC prior to start of FERRIPROX therapy and monitor on the following schedule during treatment:
- First six months of therapy: Monitor ANC weekly;
- Next six months of therapy: Monitor ANC once every two weeks;
- After one year of therapy: Monitor ANC every two to four weeks (or at the patient's blood transfusion interval in patients that have not experienced an interruption due to any decrease in ANC [see Warnings and Precautions (5.1)].
Due to the risk of hepatic transaminase elevations, monitor ALT before and monthly during FERRIPROX therapy [see Warnings and Precautions (5.2)].
Due to the risk of zinc deficiency, monitor zinc levels before and regularly during FERRIPROX therapy [see Warnings and Precautions (5.3)].
Recommended Dosage for FERRIPROX Oral Solution for Adult and Pediatric Patients with Transfusional Iron Overload due to Thalassemia Syndromes, Sickle Cell Disease or Other Anemias
The recommended starting oral dosage of FERRIPROX Oral Solution is 25 mg/kg (actual body weight), three times per day for a total of 75 mg/kg/day. Round dose to the nearest 2.5 mL.
To minimize gastrointestinal upset when first starting therapy, dosing can start at 45 mg/kg/day and increase weekly by 15 mg/kg/day increments until the full prescribed dose is achieved.
Tailor dosage adjustments to the individual patient's response and therapeutic goals (maintenance or reduction of body iron burden). The maximum oral dosage is 33 mg/kg (actual body weight), three times per day for a total of 99 mg/kg/day.
Monitoring Ferritin Levels to Assess Efficacy
Monitor serum ferritin concentration every two to three months to assess the effect of FERRIPROX on body iron stores. If the serum ferritin is consistently below 500 mcg/L, consider temporarily interrupting FERRIPROX therapy until serum ferritin rises above 500 mcg/L.
More about Ferriprox (deferiprone)
- Side effects
- Drug interactions
- Dosage information
- During pregnancy or Breastfeeding
- Imprints, shape & color data
- Compare alternatives
- Pricing & coupons
- Generic availability
- En español
- Drug class: antidotes
- FDA approval history
- Drug Information
- Ferriprox (Advanced Reading)
- Ferriprox (Deferiprone Oral Solution)
- Ferriprox (Deferiprone Tablets)
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.