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Chlorophyllin Copper Complex / Papain / Urea Topical Dosage

Applies to the following strengths: 0.5%-521,700 units/g-10%; 0.5%-520,000 units/g-10%

Usual Adult Dose for Dermatologic Lesion

Chlorophyllin copper com/papain/urea topical ointment:
The wound should be cleansed with isotonic saline or a mild wound cleanser. After cleansing, the ointment should be applied directly to the wound and covered with an appropriate dressing. While application 1 to 2 times daily is preferred, longer intervals of up to 2 to 3 days have been reported.

Chlorophyllin copper com/papain/urea topical spray:
The wound should be cleansed with isotonic saline or a mild wound cleanser. After cleansing, the spray should be applied 1 to 2 inches from the affected area until the wound is completely covered. A dressing of choice should then be applied. While application 1 to 2 times daily is preferred, longer intervals of up to 2 to 3 days have been reported.

Usual Adult Dose for Burns - External

Chlorophyllin copper com/papain/urea topical ointment:
The wound should be cleansed with isotonic saline or a mild wound cleanser. After cleansing, the ointment should be applied directly to the wound and covered with an appropriate dressing. While application 1 to 2 times daily is preferred, longer intervals of up to 2 to 3 days have been reported.

Chlorophyllin copper com/papain/urea topical spray:
The wound should be cleansed with isotonic saline or a mild wound cleanser. After cleansing, the spray should be applied 1 to 2 inches from the affected area until the wound is completely covered. A dressing of choice should then be applied. While application 1 to 2 times daily is preferred, longer intervals of up to 2 to 3 days have been reported.

Usual Adult Dose for Wound Debridement

Chlorophyllin copper com/papain/urea topical ointment:
The wound should be cleansed with isotonic saline or a mild wound cleanser. After cleansing, the ointment should be applied directly to the wound and covered with an appropriate dressing. While application 1 to 2 times daily is preferred, longer intervals of up to 2 to 3 days have been reported.

Chlorophyllin copper com/papain/urea topical spray:
The wound should be cleansed with isotonic saline or a mild wound cleanser. After cleansing, the spray should be applied 1 to 2 inches from the affected area until the wound is completely covered. A dressing of choice should then be applied. While application 1 to 2 times daily is preferred, longer intervals of up to 2 to 3 days have been reported.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Chlorophyllin copper com/papain/urea topical should not be used in eyes.

The profuse exudate resulting in enzymatic digestion may cause irritation. In these cases, more frequent changes of dressings until exudate diminishes will alleviate discomfort.

Dialysis

Data not available

Other Comments

Cleansing with hydrogen peroxide solution should be avoided since it may inactivate the papain.

Upon first use of topical spray, the nozzle should be gently depressed to break the seal. The spray should be applied in a single layer to cover wound bed. Note that application of cover dressing (gauze or appropriate dressing of choice) should cause the drug to disperse for additional coverage. The nozzle should be wiped clean with gauze after each use. It is not necessary to prime or shake the bottle.

Chlorophyllin copper com/papain/urea may be applied under pressure dressings.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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