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Cenegermin Ophthalmic Dosage

Applies to the following strengths: bkbj 0.002%

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Keratitis

Instill 1 drop in affected eye(s) 6 times per day at 2-hour intervals
Duration of therapy: 8 weeks

Comments:

  • If more than 1 topical ophthalmic product is being used, administer eye drops at least 15 minutes apart to avoid diluting products.
  • This drug should be administered 15 minutes prior to any eye ointment, gel, or other viscous eye drop.
  • Consult other comments for specific administration advice.

Use: For the treatment of neurotrophic keratitis.

Usual Pediatric Dose for Keratitis

2 years or older:
Instill 1 drop in affected eye(s) 6 times per day at 2-hour intervals
Duration of therapy: 8 weeks

Comments:

  • If more than 1 topical ophthalmic product is being used, administer eye drops at least 15 minutes apart to avoid diluting products.
  • This drug should be administered 15 minutes prior to any eye ointment, gel, or other viscous eye drop.
  • Consult other comments for specific administration advice.

Use: For the treatment of neurotrophic keratitis.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Precautions

CONTRAINDICATIONS:

  • None

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

  • For ocular use only
  • Remove contact lenses before instilling drops; may reinsert lenses 15 minutes following administration
  • If more than 1 topical ophthalmic product is being administered, separate administration by at least 15 minutes to avoid diluting products; administer this drug 15 minutes prior to any eye ointment, gel, or other viscous eye drops
  • Supplied in a weekly carton containing 7 multiple-dose vials in an insulated pack with 8 vial adapters, 45 pipettes, 45 sterile disinfectant wipes, and a dose card; patient should be instructed to refrigerate weekly carton within 5 hours of receiving from pharmacy
  • If treatment is started immediately, it will be necessary to wait until the first vial is thawed (carton is stored in freezer at the pharmacy; thawing may take up to 30 minutes at room temperature); do not shake vial
  • Follow instructions (steps 1 thru 19) included in Patient Information/Instructions for Use pamphlet
  • To ensure accurate dosing, patient should consider setting an alarm as a reminder for dosing

Missed dose: If a dose is missed, continue treatment at next scheduled administration

Storage requirements:
  • Prior to dispensing from pharmacy: Store in the freezer at or below -4F (-20C)
  • Dispense weekly carton in the insulated pack in the Delivery System Kit
  • Following dispensing: Weekly carton should be stored in the refrigerator (36F to 46F [2C to 8C]) within 5 hours of removing from freezer; may be stored refrigerated for up to 14 days
  • Open vials should be stored in the original carton in the refrigerator or at room temperature (up to 77F [25C]); unused portion of open vial should be discarded after 12 hours
  • Do not refreeze; do not shake

Patient advice:
  • Read the US FDA-approved patient labeling (Patient Information and Instructions for Use).
  • Vinson may be blurred for a short time after using this drug; if this happens, do not drive or operate hazardous machinery until vision clears.

Frequently asked questions

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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.