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CaverJect Dosage

Generic name: ALPROSTADIL 20.5ug in 1mL
Dosage form: injection, powder, lyophilized, for solution

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The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Important Dosage and Administration Instructions

  • CAVERJECT is available in single-dose vials containing 20 mcg or 40 mcg of alprostadil. Make sure a new, correct strength vial of CAVERJECT is used for each patient dosage preparation.
  • Administration of the first injections of CAVERJECT should be done in the physician's office by medically trained personnel.
  • Carefully titrate the dose of CAVERJECT for each patient to the lowest effective dose.
  • Instruct the patient on proper use and assess that they are well trained in the self-injection technique prior to initiation of home use. Advise the patient to read and carefully follow the Patient Information and Instructions for Use.

Recommended Dosage for Erectile Dysfunction

Erectile Dysfunction of Vasculogenic, Psychogenic, or Mixed Etiology

  • Initiate dosing with 2.5 mcg of alprostadil.
  • If there is a partial response at 2.5 mcg, the dose may be increased to 5 mcg within 1 hour. Use a new vial for each dose of CAVERJECT.
  • During titration, no more than 2 doses should be given within a 24-hour period.
  • The optimal dose should produce an erection suitable for intercourse that does not exceed a duration of 1 hour.
  • The patient must stay in the physician's office until complete detumescence occurs.

If additional titration is required, doses in increments of 5 to 10 mcg may be given at least 24 hours apart. Repeat the titration as necessary until the optimal dose is achieved. Doses greater than 60 mcg are not recommended.

Erectile Dysfunction of Pure Neurogenic Etiology (e.g., Spinal Cord Injury).

  • Initiate dosing with 1.25 mcg of alprostadil.
  • If there is a partial response, the dose may be increased to 2.5 mcg within 1 hour. Use a new vial for each dose of CAVERJECT.
  • During titration, no more than 2 doses should be given within a 24-hour period.
  • The optimal dose should produce an erection suitable for intercourse that does not exceed a duration of 1 hour.
  • The patient must stay in the physician's office until complete detumescence occurs.

If additional titration is required, a dose of 5 mcg may be given during the next 24 hours. Thereafter, doses in increments of 5 mcg may be given at least 24 hours apart until the optimal dose is reached. Doses greater than 60 mcg are not recommended.

Maintenance Dosage for Patient Home Use

  • Once the dose of CAVERJECT has been determined in the physician's office, additional dose adjustment may be required after consultation with the physician. Adjust the dose in accordance with the titration guidelines described above.
  • The recommended frequency of injection is no more than 3 times weekly, with at least 24 hours between each dose.
  • Re-evaluate patients regularly (every 3 months or as clinically appropriate) and determine if dosage adjustments are needed.

Preparation Instructions

Supplies Needed and Not Supplied With CAVERJECT

  • 1 mL of the diluent (bacteriostatic water for injection preserved with benzyl alcohol 0.945% w/v)
  • 1 mL to 3 mL syringe, dependent on the titrated dose
  • 21 to 27 gauge needle for reconstitution
  • 29 or 30 gauge one-half inch needle for injection
  • alcohol swabs

Reconstitution Instructions

  • CAVERJECT vial(s): Using the correct strength vial containing 20 mcg or 40 mcg of CAVERJECT, use a 1 mL to 3 mL syringe, a 21 to 27 gauge needle and 1 mL of the diluent (bacteriostatic water for injection preserved with benzyl alcohol 0.945% w/v) for reconstitution. Reconstitution results in CAVERJECT 20 mcg/mL or 40 mcg/mL.
  • Visually inspect the solution in the vial for particulate matter and discoloration. Do not use the solution if it is cloudy, colored or contains particles.
Table 1: Volume of CAVERJECT Solution to Inject using 1 mL syringe
20 mcg Vial 40 mcg Vial
Dose Volume to Inject Dose Volume to Inject
1.25 mcg 0.06 mL 1.25 mcg ---
2.5 mcg 0.125 mL 2.5 mcg ---
5 mcg 0.25 mL 5 mcg 0.125 mL
10 mcg 0.5 mL 10 mcg 0.25 mL
15 mcg 0.75 mL 15 mcg 0.375 mL
20 mcg 1 mL 20 mcg 0.5 mL
25 mcg --- 25 mcg 0.625 mL
30 mcg --- 30 mcg 0.75 mL
40 mcg --- 40 mcg 1 mL
  • Draw the dose of CAVERJECT into the syringe.
  • Replace the needle used for reconstitution with a 29 or 30 gauge one-half inch needle prior to injection.
  • The reconstituted solution should be used within 24 hours when stored at or below 25°C (77°F).

Refer to the Patient Information and Instructions for Use in the FDA-approved patient labeling for the complete detailed instructions on reconstitution and needle preparation steps.

Administration Instructions

  • Use a 29 or 30 gauge one-half inch needle for injecting each dose.
  • The patient should be in a sitting or slightly reclined position when injecting a dose.
  • Retract the foreskin in uncircumcised patients.
  • Grasp the head of the penis with the thumb and forefinger and stretch it length-wise along the thigh.
  • The site of injection is either the right or left lateral penis. See Figures A and B below.

Figure A

Figure B

Figure A Figure B
  • Wipe the intended injection site with an alcohol swab prior to injection.
  • Insert needle perpendicular to the long dorsolateral penile axis in the proximal third of penis. Avoid angulation of the syringe and do not bend the needle.
  • Avoid visible veins during injection.
  • With each use of CAVERJECT, alternate the side of the penis that is injected.
  • Compress the site of injection with an alcohol swab or sterile gauze for 5 minutes.
  • CAVERJECT is intended for single patient use only and should be discarded after use.

Adjunct to the Diagnosis of Erectile Dysfunction

As an adjunct to the diagnosis of erectile dysfunction, inject CAVERJECT intracavernosally and monitor patients for the occurrence of an erection. Extensions of this testing are the use of CAVERJECT as an adjunct to laboratory investigations, such as duplex or Doppler ultrasound imaging. For any of these tests, use a single dose of CAVERJECT that induces a rigid erection.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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