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Aminophylline Dosage

Applies to the following strength(s): 225 mg ; 105 mg/5 mL ; 100 mg ; 200 mg ; 25 mg/mL ; 250 mg ; 500 mg

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Asthma - Acute

IV: (all dosages based on aminophylline-patient not receiving aminophylline or theophylline}
Loading dose:
6 mg/kg in 100 to 200 mL of IV fluid intravenously once over 20 to 30 minutes.
Maintenance dose (following loading dose):
Otherwise healthy nonsmoking adult: 0.7 mg/kg/hr continuous intravenous infusion.
Young adult smoker: 0.9 mg/kg/hr continuous intravenous infusion.
Patient with cor pulmonale or congestive heart failure: 0.25 mg/kg/hr continuous intravenous infusion.

Oral: (Patient not receiving aminophylline or theophylline)
Loading dose: 6.3 mg/kg orally once.
Maintenance dose (following loading dose):
Otherwise healthy nonsmoking adult: 12.5 mg/kg/day in divided doses. Do not exceed 1,125 mg/day.
Young adult smoker: 19 mg/kg/day in divided doses.
Patient with cor pulmonale or congestive heart failure: 6.25 mg/kg/day in divided doses. Do not exceed 500 mg/day.

Usual Geriatric Dose for Asthma - Acute

IV: (all dosages based on aminophylline)
Patient not receiving aminophylline or theophylline:
Loading dose: 6 mg/kg in 100 to 200 mL of IV fluid intravenously once over 20 to 30 minutes.
Maintenance dose (following loading dose): 0.2 to 0.3 mg/kg/hr continuous intravenous infusion.

Oral: Patient not receiving aminophylline or theophylline:
Loading dose: 6.3 mg/kg orally once.
Maintenance dose (following loading dose): 1.7 to 2 mg/kg orally every 8 hours.

Usual Pediatric Dose for Apnea of Prematurity

<= 4 weeks: (IV or oral, all dosages based on aminophylline):
Loading dose: (Patient not receiving aminophylline or theophylline): 5 to 6 mg/kg once - if IV, dilute in IV fluid and give intravenously once over 20 to 30 minutes.
Maintenance dose: 3 to 8 mg/kg/day divided every 6 to 12 hours.

Usual Pediatric Dose for Asthma - Acute

IV: (all dosages based on aminophylline and patient not receiving aminophylline or theophylline):
Loading dose:: 6 mg/kg diluted in IV fluid intravenously once over 20 to 30 minutes.
Maintenance dose (following loading dose):
6 weeks to 6 months: 0.5 mg/kg/hour continuous intravenous infusion.
6 months to 1 year: 0.6 to 0.7 mg/kg/hr continuous intravenous infusion.
1 year to 9 years: 1 to 1.2 mg/kg/hr continuous intravenous infusion.
9 years to 12 years: 0.9 mg/kg/hr continuous intravenous infusion.
>12 years: 0.7 mg/kg/hr continuous intravenous infusion.

Oral: (Patient not receiving aminophylline or theophylline):
Loading dose: 6.3 mg/kg orally once.
Maintenance dose (following loading dose):
>=42 < 182 days: 12 to 13.5 mg/kg/day in divided doses.
>= 6 < 12 months: 15 to 22.5 mg/kg/day in divided doses.
>=1 year to <9 years: 25 to 30 mg/kg/day in divided doses.
>=9 years to <12 years: 17 to 20 mg/kg/day in divided doses.
>=12 to <16 years: 15 to 17 mg/kg in divided doses.
>=16 years: 6.25 to 20 mg/kg orally divided every 6 hours.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Loading dose: 6 mg/kg (patient not receiving aminophylline or theophylline) diluted in IV fluid at a rate not more than 25 mg/min.
Maintenance dose: 0.25 mg/kg/hr continuous intravenous infusion.

Dose Adjustments

In patients receiving theophylline, each 0.5 mg/kg theophylline (0.6 mg/kg aminophylline) administered as a loading dose will increase serum theophylline level by 1 mcg/mL.

Dialysis

Aminophylline (theophylline) is somewhat removed with hemodialysis. A 50% supplemental dose or administering the dose post dialysis is recommended. A supplemental dose is not needed with peritoneal dialysis.

Other Comments

Serum levels may be obtained 15 to 30 minutes following an IV loading dose.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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