Aminoglutethimide Dosage

Usual Adult Dose for Cushing's Syndrome

250 mg orally every 6 hours. Adrenocortical response should be monitored carefully, preferably in a hospital setting, while initiating therapy. If cortical suppression is inadequate, the dose may be titrated in 250 mg increments every 1 to 2 weeks to a maximum daily dose of 2 g.

Usual Adult Dose for Breast Cancer

250 mg orally twice a day. The dose may be increased after 2 weeks to 250 mg orally 4 times a day based on clinical response and patient tolerance of the drug. The typical dosage range is 250 to 1000 mg/day. Aminoglutethimide is usually used concomitantly with either hydrocortisone or cortisone acetate in this clinical setting to prevent ACTH reflex phenomenon.

Usual Adult Dose for Prostate Cancer

250 mg orally twice a day. The dose may be increased after 2 weeks to 250 mg orally 4 times a day based on clinical response and patient tolerance of the drug. The typical dosage range is 250 to 1000 mg/day. Aminoglutethimide is usually used concomitantly with either hydrocortisone or cortisone acetate in this clinical setting to prevent ACTH reflex phenomenon.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Patients with renal or liver dysfunction should be carefully monitored for aminoglutethimide toxicity. Dosing should be conservative.

Dialysis

Data not available

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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